PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Early clinical trials for Hypoxis rooperi showed mixed efficacy results, with some suggesting possible benefit, but evidence is considered questionable or inconclusive due to poor product standardization and study design [PMID:27180172, PMID:12084323].
In vitro and xenograft models show beta-sitosterol suppresses proliferation, induces apoptosis, and enhances sensitivity to 5-fluorouracil and oxaliplatin [PMID:40889204].
In mouse models, beta-sitosterol significantly ameliorated colonic inflammation and reduced inflammatory mediators like IL-6 and iNOS [PMID:40400313].
In xenograft mouse models, beta-sitosterol significantly inhibited HepG2 cell proliferation, migration, and invasion [PMID:38063438].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 27180172 (2016) — Phytotherapy for Benign Prostatic Hyperplasia. · Current urology reports
- 2.PMID: 32527245 (2020) — African potato (Hypoxis hemerocallidea): a systematic review of its chemistry, pharmacology and ethno medicinal properties. · BMC complementary medicine and therapies
- 3.PMID: 11276294 (2000) — Phytotherapy for benign prostatic hyperplasia. · Public health nutrition
- 4.PMID: 39165938 (2024) — β-sitosterol alleviates atherosclerosis by regulating catalase. · Heliyon
- 5.PMID: 28710625 (2017) — Selection of Biodegrading Phytosterol Strains. · Methods in molecular biology (Clifton, N.J.)