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PubMed · A review of <i>Phyllanthus urinaria</i> L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma. (2024)
PubMed · A Review: Mechanism of <i>Phyllanthus urinaria</i> in Cancers-NF-<i>κ</i>B, P13K/AKT, and MAPKs Signaling Activation. (2021)
Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Phyllanthus urinaria is a medicinal herb with reported antiviral, antibacterial, anti-inflammatory, and anticancer properties [PMID:34484390, PMID:30327602].
Background
Phyllanthus urinaria (L.) is an annual perennial herbal species found in tropical Asia, America, China, and the Indian Ocean islands [PMID:30327602]. It is extensively used as ethnopharmacological material in China [PMID:36684764] and in West Africa [PMID:37716546].
Traditional uses
In folk medicine, it is used to treat jaundice, diabetes, malaria, and liver diseases [PMID:30327602]. In West Africa, the aerial parts are used against helminthiasis [PMID:37459860].
Active compounds
The plant contains flavonoids, lignans (such as 5-demethoxyniranthin, urinatetralin, dextrobursehernin, and urinaligran), tannins (including corilagin), phenolics, and terpenoids [PMID:12877924, PMID:39185304, PMID:36635908, PMID:30327602]. Specific identified compounds include gallic acid, brevifolin carboxylic acid, phyllanthusiin C, ellagic acid, and stigmasterol glucoside [PMID:19295228, PMID:30068884].
Mechanism of action
Anticancer mechanisms involve the modulation of NF-κB, P13K/AKT, and ERK/JNK/P38/MAPKs signaling pathways [PMID:34484390]. It induces apoptosis via DNA fragmentation and increased caspase-3 activity through intrinsic and extrinsic pathways, and may down-regulate telomerase activation [PMID:20979698, PMID:15135654]. In osteosarcoma cells, it is associated with the modulation of mitochondrial fission/fusion machinery and induction of mitochondrial dysfunction [PMID:27776427, PMID:24836433]. Anti-inflammatory effects are facilitated by reducing pro-inflammatory cytokine production and inhibiting prostaglandin and nitric oxide synthesis [PMID:40271556].
Clinical evidence
Evidence BNon-alcoholic steatohepatitis (NASH)
A placebo-controlled double-blind randomized trial was conducted to test if P. urinaria was superior to placebo in improving histological NAFLD activity score over 24 weeks [PMID:23034128].
Demonstrates potential in the treatment of liver disease, though detailed pharmacological mechanisms remain scarce [PMID:39185304].
Evidence DCancer
In vitro and in vivo evidence shows reduction of cell viability in various cancer lines and suppression of tumor development in mice [PMID:20979698, PMID:27776427].
Evidence DAndrogen-derived alopecia
Extract showed hair regrowth activity in mice at 5 mg/mouse/d and inhibited 5α-reductase [PMID:30068884].
Safety & adverse effects
A therapeutic dose of P. urinaria extract did not show any toxicological phenomenon in mice [PMID:19386480].
Evidence summary
The evidence consists primarily of in vitro studies, animal models (mice/broilers), and reviews, with one randomized controlled trial for NASH. Overall strength is low to moderate, predominantly preclinical.
PubMed sources
1.PMID: 34484390 (2021) — A Review: Mechanism of Phyllanthus urinaria in Cancers-NF-κB, P13K/AKT, and MAPKs Signaling Activation. · Evidence-based complementary and alternative medicine : eCAM
2.PMID: 12877924 (2003) — Lignans from Phyllanthus urinaria. · Phytochemistry
3.PMID: 39185304 (2024) — A review of Phyllanthus urinaria L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma. · Frontiers in pharmacology
4.PMID: 20979698 (2010) — Anti-cancer effects of Phyllanthus urinaria and relevant mechanisms. · Chang Gung medical journal
5.PMID: 36635908 (2023) — Agent in Urgent Need of Clinical Practice: Corilagin.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 36684764 (2022) — Application of chloroplast genome in the identification of Phyllanthus urinaria and its common adulterants. · Frontiers in plant science
7.PMID: 30327602 (2018) — A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L. · Frontiers in pharmacology
8.PMID: 30068884 (2018) — Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase. · Biological & pharmaceutical bulletin
9.PMID: 40271556 (2025) — An Updated Review on the Anti-Inflammatory Potential of Phyllanthus Genus. · Chemistry & biodiversity
10.PMID: 18157836 (2008) — Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo. · Hepatology (Baltimore, Md.)
11.PMID: 15135654 (2004) — Phyllanthus urinaria induces the Fas receptor/ligand expression and ceramide-mediated apoptosis in HL-60 cells. · Life sciences
12.PMID: 27776427 (2016) — Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery. · The American journal of Chinese medicine
13.PMID: 19386480 (2009) — Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. · Phytomedicine : international journal of phytotherapy and phytopharmacology
14.PMID: 35503410 (2023) — Metabolomics analysis of differential chemical constituents and α-glucosidase inhibiting activity of Phyllanthus urinaria L. root, stem, leaf and fruit. · Natural product research
15.PMID: 19295228 (2009) — Phyllanthus urinaria increases apoptosis and reduces telomerase activity in human nasopharyngeal carcinoma cells. · Forschende Komplementarmedizin (2006)
16.PMID: 24836433 (2014) — Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins. · Mitochondrion
17.PMID: 26220282 (2015) — Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro. · BMC complementary and alternative medicine
18.PMID: 23034128 (2013) — Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria: a randomized trial. · Journal of gastroenterology and hepatology
19.PMID: 37716546 (2023) — Towards the development of analytical monograph specifications for the quality assessment of the medicinal plant Phyllanthus urinaria. · Phytochemistry
20.PMID: 37459860 (2023) — Anthelmintic Activities of Extract and Ellagitannins from Phyllanthus urinaria against Caenorhabditis elegans and Zoonotic or Animal Parasitic Nematodes. · Planta medica