PubMed-compiled information sheet
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Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Total saponins from Dioscorea (Bi Xie extract) significantly decreased serum uric acid levels in rats, showing effects similar to allopurinol [PMID:27072969].
Bi Xie Fen Qing Yin decoction reduced plasma uric acid, improved renal function, suppressed NLRP3 inflammasome activation, and improved gut microbiota dysbiosis in mice [PMID:38147734].
Methanol extract of Dioscoreae Rhizoma (D. tokoro) reduced the proliferation of human fibroblast-like synovial cells stimulated by IL-1beta and TNF-alpha [PMID:15351318].
Qing-Luo-Yin (containing D. hypoglauca) ameliorated articular morphological alterations, over-expression of MMP-3 mRNA, and reduced TIMP-1 production in rats [PMID:14696674].
Evidence summary
PubMed sources
- 1.PMID: 29218932 (2017) — [Research progress of Bixie]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- 2.PMID: 38147734 (2024) — Bi Xie Fen Qing Yin decoction alleviates potassium oxonate and adenine induced-hyperuricemic nephropathy in mice by modulating gut microbiota and intestinal metabolites. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 3.PMID: 15351318 (2004) — Methanol extract of Dioscoreae Rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis. · International immunopharmacology
- 4.PMID: 27072969 (2016) — Total saponins from dioscorea septemloba thunb reduce serum uric acid levels in rats with hyperuricemia through OATP1A1 up-regulation. · Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
- 5.