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Compiled from 27 PubMed articles · model: gemma4:31b
Summary
Bilberry (Vaccinium myrtillus) is a berry-bearing shrub rich in anthocyanins and tannins, used primarily for eye disorders and metabolic health [PMID:30000885, PMID:22593936].
Background
Vaccinium myrtillus L., commonly known as bilberry, is an economically important wild berry in Northern Europe that thrives in acidic, nutrient-poor soils [PMID:37836403, PMID:39339606].
Traditional uses
Bilberry has been used in European folk medicine to stop milk flow [PMID:30000885] and in traditional medicine for treating microvascular disorders, inflammatory conditions, and urinary system ailments [PMID:42229624]. Leaves are traditionally used in many countries to treat a variety of diseases [PMID:36678645], and fruits are used to treat non-specific diarrhea and symptoms related to varicose veins [PMID:33587635].
Active compounds
The fruit contains anthocyanins, tannins, phenolic acids, organic acids, coumarins, flavonols, flavanols, terpenoids, and volatile chemicals [PMID:30000885, PMID:36286028]. Leaves contain phenolic acids (notably chlorogenic acid), flavonoids (notably isoquercetin), and resveratrol [PMID:33809607].
Mechanism of action
Bilberry exerts anti-inflammatory effects by lowering expression of tumor necrosis factor-α, interleukin (IL)-6, and IL-1β, and by altering nuclear factor kappa B and Janus kinase-signal transducer and activator of transcription signaling pathways [PMID:36286028]. Its anthocyanins act as potent antioxidants [PMID:37836403]. Additionally, bilberry extracts may inhibit α-amylase, potentially decreasing postprandial blood glucose levels [PMID:37570789].
Clinical evidence
Evidence ANight Vision
Rigorous clinical studies do not support the hypothesis that V. myrtillus anthocyanosides improve normal night vision [PMID:14711439].
Evidence CType 2 Diabetes
Clinical studies on vision disorders and diabetes show contradictory results with no clear conclusion on benefits [PMID:35847049]. Animal and in vitro studies strongly indicate potential to ameliorate T2D, but appropriate clinical trials are needed [PMID:27748191].
Evidence CColorectal Cancer
Experimental studies indicate that bilberry inhibits colorectal cancer progression [PMID:34073356].
Evidence DDiabetic Kidney Disease
In mouse models, water-soluble anthocyanin-rich bilberry extract showed renoprotective effects by targeting ALOX15-mediated lipid peroxidation [PMID:42229624].
Safety & adverse effects
Bilberry preparations are generally well tolerated as food, but should be avoided by individuals allergic to bilberry, cranberry, blueberry, or other Vaccinium species [PMID:30000885].
Pregnancy & lactation
No data exist on the excretion of bilberry components into breastmilk or on the safety and efficacy in nursing mothers or infants; recommendations on using large quantities during breastfeeding cannot be made [PMID:30000885].
Drug interactions
In rats, bilberry extract significantly increased the activity of cytochrome P450 (CYP) 2C11 and CYP2E1 after 29 days of administration [PMID:31059744].
Evidence summary
The evidence is mixed. While preclinical (animal/cell) data strongly support anti-inflammatory, antioxidant, and metabolic benefits, rigorous clinical evidence for vision and diabetes is lacking or contradictory.
PubMed sources
1.PMID: 30000885 (2006) — [Vaccinium myrtillus]. · Archivos de la Sociedad Espanola de Oftalmologia
2.PMID: 36286028 (2022) — Anti-Inflammatory Activity of Bilberry (Vaccinium myrtillus L.). · Current issues in molecular biology
3.PMID: 37836403 (2023) — Vaccinium uliginosum and Vaccinium myrtillus-Two Species-One Used as a Functional Food. · Nutrients
4.PMID: 22593936 (2011) — Herbal Medicines in Glaucoma Treatment. · The Yale journal of biology and medicine
5.PMID: 39339606 (2024) — Bilberry Expansion in the Changing Subalpine Belt. · Plants (Basel, Switzerland)
6.PMID: 27748191 (2017) — A Brief Review of Blue- and Bilberries' Potential to Curb Cardio-Metabolic Perturbations: Focus on Diabetes. · Current pharmaceutical design
7.PMID: 42229624 (2026) — Water-soluble anthocyanins from Vaccinium myrtillus L. alleviate diabetic kidney disease by targeting ALOX15-mediated lipid peroxidation. · Journal of ethnopharmacology
8.PMID: 37570789 (2023) — Inhibitory Potential of Different Bilberry (Vaccinium myrtillus L.) Extracts on Human Salivary α-Amylase. · Molecules (Basel, Switzerland)
9.PMID: 36678645 (2022) — An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology. · Pharmaceutics
10.PMID: 33587635 (2021) — Quality Assessment of Bilberry Fruits (Vaccinium myrtillus) and Bilberry-Containing Dietary Supplements. · Journal of agricultural and food chemistry
11.PMID: 31059744 (2019) — Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
12.PMID: 40264677 (2025) — Vaccinium myrtillus L. ameliorates diabetic nephropathy via modulating metabolites and gut microbiota in rats. · Frontiers in pharmacology
13.PMID: 34073356 (2021) — Anticancer Effects of Lingonberry and Bilberry on Digestive Tract Cancers. · Antioxidants (Basel, Switzerland)
14.PMID: 14711439 (2004) — Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials. · Survey of ophthalmology
15.PMID: 33809607 (2021) — Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation. · Antioxidants (Basel, Switzerland)
16.PMID: 35847049 (2022) — Bilberries: Curative and Miraculous - A Review on Bioactive Constituents and Clinical Research. · Frontiers in pharmacology
17.PMID: 32864929 (2020) — The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm. · Brazilian journal of cardiovascular surgery