PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Borneol exhibits neuroprotective effects and can be used in delivery systems to restore intracellular Ca2+ and redox homeostasis while inhibiting apoptosis pathways [PMID:39804950, PMID:34017247]
Borneol is applied in the protection and treatment of CVDs due to anti-inflammatory, anti-oxidant, and anti-coagulant activities [PMID:36087846, PMID:33892091]
Natural borneol combined with sodium valproate (VPA) showed augmented efficacy in vivo by inhibiting TAGLN/HDAC2 function [PMID:38087889]
L-borneol promotes the differentiation of hair follicle stem cells into basal layer cells to repair skin wounds [PMID:40378434]; alum-borneol combinations are used in clinical burn treatment [PMID:35731421]
Borneol enantiomers can inhibit P-glycoprotein (Pgp), thereby increasing the accumulation of drugs like mitoxantrone in cells [PMID:33378196]
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 38087889 (2024) — Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation. · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- 2.PMID: 37321057 (2023) — Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 3.PMID: 39804950 (2025) — Traditional Chinese Medicine Borneol-Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis-Adaptive Treatment of Ischemic Stroke. · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- 4.PMID: 34104738 (2021) — The complete chloroplast genome sequence of Dryobalanops aromatica. · Mitochondrial DNA. Part B, Resources
- 5.PMID: 36793954