PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 28 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
A topical gel (Oleogel-S10) consisting of 10% dry birch bark extract significantly increased the proportion of patients with first complete target wound closure within 45 days compared to control gel [PMID:37658982, PMID:42205007].
Topical application of Betula alba (birch bark extract) increased skin hydration and reduced transepidermal water loss in humans in vivo [PMID:21709432].
Birch bark is listed as a herbal biomedicine tested for the treatment of actinic keratosis [PMID:32046246].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 37658982 (2023) — Birch Bark Extract: A Review in Epidermolysis Bullosa. · Drugs
- 2.PMID: 35684557 (2022) — Methods of Betulin Extraction from Birch Bark. · Molecules (Basel, Switzerland)
- 3.PMID: 37509141 (2023) — Pharmacological Potential of Betulin as a Multitarget Compound. · Biomolecules
- 4.PMID: 31580010 (2020) — Antimicrobial activity and chemical composition of white birch (Betula papyrifera Marshall) bark extracts. · MicrobiologyOpen
- 5.PMID: 31168940 (2019) — Mechanism of Oleogel-S10: A triterpene preparation for the treatment of epidermolysis bullosa. · Dermatologic therapy