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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Lotus corniculatus, known as Bird's Foot Trefoil, is a perennial legume used as a high-quality forage crop [PMID: 37071467, 40134620] and a traditional medicinal herb [PMID: 32178424, 41507713].
Background
Bird's Foot Trefoil (Lotus corniculatus) is a widely distributed perennial leguminous herb [PMID: 37592232, 40134620]. It is valued for its high nutritive value, ability to grow in low-fertility, acidic, and high-salinity soils, and its role in grassland ecological restoration [PMID: 33537439, 37071467].
Traditional uses
In Turkish traditional medicine, aerial parts are used as a sedative, diuretic, antihemoroidal, and painkiller [PMID: 32178424]. In Persian folk medicine, it is used to treat back pain and peritoneal inflammation [PMID: 37734474]. In Traditional Chinese Medicine (TCM), the roots are used for eczema, hemorrhoids, fever due to Yin deficiency, and coughing due to wind-heat [PMID: 41507713].
Active compounds
Phytochemicals include condensed tannins [PMID: 37071467], proanthocyanidins (PAs) [PMID: 39557697], cyanogenic glycosides [PMID: 37592232], and flavonoids such as (-)-vestitol [PMID: 41507713]. Other identified compounds include kaempferol, afzelin, kaempferitin, and a galloyl glucoside (2,6-di-O-acetyl 1-O-galloyl β-D-glucose) [PMID: 32755245, 29656654].
Mechanism of action
The plant's essential oil and oleanolic acid may exert antinociceptive activity involving the NO-cGMP-K+ channel, TRPV, dopamine, cannabinoid, PPAR, adrenergic, and opioid mechanisms [PMID: 37734474]. Its flavonoids, specifically (-)-vestitol, are reported to exhibit anti-inflammatory, anticancer, and antiviral activities [PMID: 41507713].
Clinical evidence
Evidence DAcute and Chronic Pain
Oral administration of Lotus corniculatus leaves essential oil (LCEO) and oleanolic acid attenuated acute pain in the first-phase of the formalin-induced paw licking test in male rats [PMID: 37734474]
Evidence DParacetamol-induced Hepatitis
Butanolic extract (100 and 200 mg/kg) showed antioxidant and anti-inflammatory effects in rats [PMID: 30799800]
Evidence DDepression
Extracts showed antidepressant potential in male BALB/c mice via tail suspension, forced swimming, and tetrabenazine-induced hypothermia tests [PMID: 32178424]
Evidence BOily Skin (Sebum Secretion)
Seed extract solution used for 4 weeks in a randomized trial reduced skin sebum contents on the forehead and cheeks [PMID: 36324215]
Evidence DCancer (Leukemic cells)
A galactose-specific lectin isolated from seeds showed strong antiproliferative activity towards human leukemic (THP-1) cancer cells [PMID: 24055517]
Evidence summary
The evidence consists primarily of in vitro studies and animal models (Level D), with one randomized controlled trial (Level B) regarding topical use for sebum reduction. No human clinical trials for systemic medicinal use were provided.
PubMed sources
1.PMID: 27325893 (2017) — Flooding tolerance of forage legumes. · Journal of experimental botany
2.PMID: 39557697 (2024) — The Lotus corniculatus MYB5 functions as a master regulator in proanthocyanidin biosynthesis and bioengineering. · Plant cell reports
3.PMID: 8241931 (1993) — The quest for a herbal contraceptive. · The National medical journal of India
4.PMID: 37071467 (2023) — X-radiation of Lotus corniculatus L. seeds improves germination and initial seedling growth. · International journal of radiation biology
5.PMID: 32178424 (2020) — Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 30799800 (2020) — Anti-inflammatory and Antioxidant Effects of Lotus corniculatus on Paracetamol-induced Hepatitis in Rats. · Anti-inflammatory & anti-allergy agents in medicinal chemistry
7.PMID: 37734474 (2024) — The oral administration of Lotus corniculatus L. attenuates acute and chronic pain models in male rats. · Journal of ethnopharmacology
8.PMID: 37592232 (2023) — Resequencing of global Lotus corniculatus accessions reveals population distribution and genetic loci, associated with cyanogenic glycosides accumulation and growth traits. · BMC biology
9.PMID: 26507574 (2016) — Therapeutic Potential of Temperate Forage Legumes: A Review. · Critical reviews in food science and nutrition
10.PMID: 3073054 (1988) — Cyanogenesis in animal-plant interactions. · Ciba Foundation symposium
11.PMID: 40134620 (2025) — The complete mitochondrial genome and phylogenetic analysis of Lotus corniculatus (Fabaceae, Papilionoideae). · Frontiers in plant science
12.PMID: 37623945 (2023) — Research on the Control of Gastrointestinal Strongyles in Sheep by Using Lotus corniculatus or Cichorium intybus in Feed. · Pathogens (Basel, Switzerland)
13.PMID: 36324215 (2023) — Inhibition of lipogenesis and sebum secretion for Lotus corniculatus seed extract in vitro and in vivo. · International journal of cosmetic science
14.PMID: 32755245 (2021) — Phytochemical and pharmacological appraisal of the aerial parts of Lotus corniculatus L. growing in Egypt. · Natural product research
15.PMID: 36938008 (2023) — Transcriptome analysis provides insights into the response of Lotus corniculatus roots to low-phosphorus stress. · Frontiers in plant science
16.PMID: 36777533 (2022) — Rhamnogalacturonan-I as a nematode chemoattractant from Lotus corniculatus L. super-growing root culture. · Frontiers in plant science
17.PMID: 24055517 (2013) — Isolation and antiproliferative activity of Lotus corniculatus lectin towards human tumour cell lines. · Phytomedicine : international journal of phytotherapy and phytopharmacology
18.PMID: 33190297 (2021) — Contrasting response of two Lotus corniculatus L. accessions to combined waterlogging-saline stress. · Plant biology (Stuttgart, Germany)
19.PMID: 24247395 (1985) — The origin of Lotus corniculatus. · TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
20.PMID: 29656654 (2019) — A new galloyl glycoside from Lotus corniculatus. · Natural product research
21.PMID: 38611490 (2024) — Relative Water Content, Chlorophyll Index, and Photosynthetic Pigments on Lotus corniculatus L. in Response to Water Deficit. · Plants (Basel, Switzerland)
22.PMID: 12489781 (2002) — Lotus corniculatus condensed tannins decrease in vivo populations of proteolytic bacteria and affect nitrogen metabolism in the rumen of sheep. · Canadian journal of microbiology
23.PMID: 33537439 (2021) — The complete chloroplast genome sequence of Lotus corniculatus L. · Mitochondrial DNA. Part B, Resources
24.PMID: 36031596 (2023) — Combined physiological responses and differential expression of drought-responsive genes preliminarily explain the drought resistance mechanism of Lotus corniculatus. · Functional plant biology : FPB
25.PMID: 36197368 (2022) — Isolation and characterization of Klebsiella oxytoca from the rhizosphere of Lotus corniculatus and its biostimulating features. · Brazilian journal of biology = Revista brasleira de biologia
26.PMID: 41507713 (2025) — [Catalytic mechanism of pterocarpan reductase in Lotus corniculatus]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
27.PMID: 41717113 (2026) — Factors affecting the genetic diversity of Lotus corniculatus in the Hemi-boreal zone of Baltic States and their agronomical implications. · Frontiers in plant science
28.PMID: 30852665 (2019) — Novel bird's-foot trefoil RNA viruses provide insights into a clade of legume-associated enamoviruses and rhabdoviruses. · Archives of virology
29.PMID: 30636646 (2019) — In vitro screening of 51 birdsfoot trefoil (Lotus corniculatus L.; Fabaceae) strains for anti-parasitic effects against Haemonchus contortus. · Parasitology
30.PMID: 40639613 (2025) — Overexpression of LcERF1 in Lotus corniculatus and Arabidopsis thaliana Reveals Its Role in Adventitious Root Formation of Hydroponic Cuttings. · Plant science : an international journal of experimental plant biology