PubMed-compiled information sheet
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Compiled from 10 PubMed articles · model: gemma4:31b
Summary
Persicaria bistorta is a perennial herb used traditionally for treating bleeding and gastrointestinal ailments [PMID:37515679, PMID:39044067].
Background
Persicaria bistorta (also known as Polygonum bistorta) is a herbaceous plant native to Europe and Asia [PMID:28407912].
Traditional uses
It is used traditionally to treat diarrhea, abdominal pain, and bleeding, and is mentioned in traditional Persian medicine for treating tissue damage and bleeding in various organs, including the intestines [PMID:37515679, PMID:39044067].
Active compounds
The plant contains flavonoids, tannins, saponins, and alkaloids [PMID:37515679]. Specific identified compounds include ethyl oleate, cyclotetradecane, dodecanoic acid, hexadecanoic acid, tetradecane, cis-13-octadecenoic acid, and bis(2-ethylhexyl) phthalate [PMID:37515679]. Aerial parts are rich in polyphenols, including quercetin and kaempferol 3-O-(5''-O-malonyl)-α-l-arabinofuranosides [PMID:28407912].
Mechanism of action
Malonylated flavonoids from the aerial parts inhibit the production of reactive oxygen species and myeloperoxidase release from stimulated human neutrophils [PMID:28407912]. In rat models of colitis, the extract's anti-inflammatory effects involve the nitric oxide and opioid systems, as well as TLR-4, IL-1β, IL-6, TNF-α, NF-κB, and myeloperoxidase [PMID:39044067].
Clinical evidence
Evidence DColitis (Rat Model)
Freeze-dried aqueous extract (300, 500, and 700 mg/kg) demonstrated anti-inflammatory effects in acetic acid-induced colitis [PMID:39044067]
Evidence DDiabetes (In vitro)
Crude ethyl acetate extracts showed dual inhibitory activity towards α-glucosidase and protein-tyrosine phosphatase 1B (PTP1B) [PMID:31119225]
Evidence DBreast Cancer (MCF-7 cell line)
Zinc oxide nanoparticles synthesized using root extract exhibited cytotoxic effects and induced apoptosis in MCF-7 cells [PMID:31573543]
Evidence summary
The current evidence is limited to in vitro studies and animal models (Level D), focusing on anti-inflammatory, antidiabetic, and cytotoxic properties.
PubMed sources
- 1.PMID: 37515679 (2024) — GC-MS Analysis of Persicaria bistorta: Uncovering the Molecular Basis of Its Traditional Medicinal Use. · Applied biochemistry and biotechnology
- 2.PMID: 28407912 (2017) — Chemical composition of edible aerial parts of meadow bistort (Persicaria bistorta (L.) Samp.). · Food chemistry
- 3.PMID: 39044067 (2024) — Protective effect of freeze-dried extract of Persicaria bistorta Samp. on acetic acid-induced colitis model in rats: Involvement of nitric oxide and opioid system. · Inflammopharmacology
- 4.PMID: 31573543 (2019) — Biosynthesis of zinc oxide nanoparticles using anjbar (root of Persicaria bistorta) extract and their cytotoxic effects on human breast cancer cell line (MCF-7). · IET nanobiotechnology
- 5.PMID: 30218970 (2018) — Green synthesis and optimization of nano-magnetite using Persicaria bistorta root extract and its application for rosewater distillation wastewater treatment.