PubMed-compiled information sheet
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Compiled from 6 PubMed articles · model: gemma4:31b
Summary
Lycopus virginicus is a plant species containing flavone glucuronides and other phenolic compounds that exhibit antithyrotropic activity [PMID:17238089, PMID:2985357].
Background
Lycopus virginicus (L.) Michx. is a member of the Lamiaceae family [PMID:17238089].
Traditional uses
Some freeze-dried extracts (FDE) of Lycopus virginicus have been used in the treatment of hyperthyroidism in Graves' disease [PMID:2985357].
Active compounds
The aerial parts of Lycopus virginicus contain 7-O-beta-D-glucuronides of apigenin, acacetin, and luteolin, as well as the methyl ester of apigenin 7-O-beta-D-glucuronide [PMID:17238089]. Active inhibitory components include luteolin-7 beta-glucoside [PMID:6724503].
Mechanism of action
Freeze-dried aqueous extracts (FDE) of Lycopus virginicus inhibit the binding of bovine TSH to human thyroid plasma membranes and the subsequent activation of adenylate cyclase [PMID:6745167]. They exert antithyrotropic activity by forming adducts with TSH that bind weakly to the TSH receptor, thereby decreasing the binding and biological action of Graves' immunoglobulins [PMID:2985357]. Additionally, aqueous extracts inhibit extrathyroidal enzymic T4-5'-deiodination to T3 and T4-5'-deiodination in rat liver microsomes [PMID:6724503].
Clinical evidence
Evidence DHyperthyroidism (Graves' disease)
Freeze-dried extracts (FDE) of Lycopus virginicus decrease the receptor-binding and biological activity of Graves' immunoglobulins [PMID:2985357].
Evidence summary
The available evidence consists primarily of in vitro studies and laboratory research demonstrating antithyrotropic and enzyme-inhibiting effects; there are no clinical trials or systematic reviews provided.
PubMed sources
- 1.PMID: 17238089 (1995) — Flavone glucuronides of Lycopus virginicus. · Planta medica
- 2.PMID: 2985357 (1985) — Extracts and auto-oxidized constituents of certain plants inhibit the receptor-binding and the biological activity of Graves' immunoglobulins. · Endocrinology
- 3.PMID: 6745167 (1984) — Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. · Endocrinology
- 4.PMID: 6724503 (1984) — Antihormonal effects of plant extracts: iodothyronine deiodinase of rat liver is inhibited by extracts and secondary metabolites of plants. · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme