PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 20 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Clinical evidence
Hexane extract from leaves exhibited strong in vitro activity against chloroquine sensitive (CQS) strain (IC50 2.53 microg/mL); isolated compounds muzigadial showed the strongest activity (IC50 0.31 microg/mL) [PMID:21299109]
Drimane sesquiterpenoids showed cytotoxicity in Chinese Hamster Ovarian (CHO) cells, with muzigadial exhibiting an IC50 of 1.18 microg/mL [PMID:21299109]. Extracts were also evaluated for cytotoxic effects against Artemia salina and breast cancer cell lines [PMID:25856874]
Canellal and an essential oil fraction from Canella winterana were tested for antimycobacterial activity, though they were not listed among the compounds that showed activity [PMID:9626931]
Evidence summary
PubMed sources
- 1.PMID: 9626931 (1998) — Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe. · FEMS immunology and medical microbiology
- 2.PMID: 25856874 (2015) — Biological screening of select Puerto Rican plants for cytotoxic and antitumor activities. · Puerto Rico health sciences journal
- 3.PMID: 30801919 (2019) — Implication of palynological techniques for the authentication of adulterated drugs traded with the same name in different herbal markets of district Lahore, Pakistan. · Microscopy research and technique
- 4.PMID: 21299109 (2010) — Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana. · Natural product communications
- 5.PMID: 11354963