PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Phyto-extracts of C. sativa in cream formulations may serve as cosmeceuticals to protect skin against the injurious effects of UV radiation [PMID:26448818]
Dietary supplementation at 1.1% in FVB/n mice reduced abdominal adipose tissue and lowered serum cholesterol [PMID:32260459]
Bark extract reduced ROS formation and improved cell viability in neonatal rat cardiomyocytes; it also induced transient negative chronotropic and positive inotropic effects in guinea pig atria [PMID:23533692]
Bark extract demonstrated antimutagenic properties against mitomycin C and vinblastine in TK6 cells, and heartwood triterpenoids showed cytotoxicity against breast (MCF-7) and prostate (PC3) cancer cell lines [PMID:37896225, PMID:28363853]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 26448818 (2015) — Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. · Oxidative medicine and cellular longevity
- 2.PMID: 36553794 (2022) — Sweet Chestnut (Castanea sativa Mill.) Nutritional and Phenolic Composition Interactions with Chestnut Flavor Physiology. · Foods (Basel, Switzerland)
- 3.PMID: 25204784 (2015) — Castanea sativa by-products: a review on added value and sustainable application. · Natural product research
- 4.PMID: 36615589 (2023) — Tannins-Based Extracts: Effects on Gut Chicken Spontaneous Contractility. · Molecules (Basel, Switzerland)
- 5.PMID: 28363853 (2017) — Cytotoxic triterpenoids isolated from sweet chestnut heartwood (Castanea sativa) and their health benefits implication.