PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
O. sinensis combined with ACEI/ARB showed a better effect on 24h urinary protein (UP), urinary albumin-to-creatinine ratio (UAER), and blood urea nitrogen (BUN) compared to ACEI/ARB alone [PMID: 25682973]
High-molecular weight polysaccharides (>300 kDa) from H. sinensis (the anamorph of O. sinensis) considerably reduced body weight gain and metabolic disorders in high-fat diet-fed mice [PMID: 30007918]
Demonstrated effectiveness through anti-inflammatory and antioxidant activities and lowering cholesterol [PMID: 38494355]
Reported to possess anticancer activity by targeting apoptosis pathways [PMID: 32774302]; ethyl acetate fractions showed significant in vitro anticancer activity [PMID: 32267545]
Used for treating hypoxia-related problems such as acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE) [PMID: 33442508]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 37513265 (2023) — Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. · Molecules (Basel, Switzerland)
- 2.PMID: 24716152 (2013) — A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao ( Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients. · Journal of traditional and complementary medicine
- 3.PMID: 30007918 (2019) — Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis. · Gut
- 4.PMID: 38494355 (2024) — Cordyceps as potential therapeutic agents for atherosclerosis. · Journal of integrative medicine
- 5.PMID: 27373780