PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Acute and subchronic administration of extracts produced antidepressant-like effects in rodent models [PMID:15991001, PMID:22728168]
Ethyl-acetate fraction (EAF) protected against cognitive impairments, reduced oxidative stress, and prevented hippocampal cell death in mice and rats [PMID:26099636, PMID:28919157, PMID:36682600]
EAF improved healing and reduced oxidative stress in TNBS-induced colitis in rats [PMID:30089249]
EAF attenuated body mass loss and improved hyperglycemia and biochemical parameters (ALP, ALT, AST) in STZ-induced diabetic rats [PMID:28662504]
Bark extracts showed in vitro antiviral activity against HSV-1 and HSV-2, including acyclovir-resistant strains [PMID:37338788, PMID:25941883]
Safety & adverse effects
Pregnancy & lactation
Evidence summary
PubMed sources
- 1.PMID: 29866157 (2018) — Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba). · BMC complementary and alternative medicine
- 2.PMID: 28970152 (2018) — In vitro multimodal-effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets. · Journal of ethnopharmacology
- 3.PMID: 15991001 (2005) — Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. · Psychopharmacology
- 4.PMID: 37338788 (2023) — Topical formulations containing Trichilia catigua extract as therapeutic options for a genital and an acyclovir-resistant strain of herpes recurrent infection. · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
- 5.PMID: 36682600