This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
CE
Not CommonAI-Generated
Centaury European
Centaurium erythraea
Digestive bitterness and appetite stimulation in ancient Greek medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Centaurium erythraea is a traditionally used medicinal plant native to Europe and Western Asia, recognized for its diverse secondary metabolites with confirmed healing properties [PMID:33396285, 39250970].
Background
Also known as common centaury or small centaury, this species belongs to the Gentianaceae family [PMID:36685651, 39250970]. It is a flowering plant with a center of diversity in the Mediterranean and western Asia [PMID:39250970].
Traditional uses
In folk medicine, it is used to treat various illnesses, including gastrointestinal disorders, diabetes, and pain [PMID:33940085, 31652501, 37948163]. Specific traditional applications include use as an antiapoplectic, anticoagulant, anticholagogue, antipneumonic, hematocathartic, hypotensive, anthelmintic, and antipyretic agent [PMID:33940085, 36309110]. It is also used externally for the treatment of wounds [PMID:36309110] and as a digestive, stomachic, tonic, depurative, and sedative [PMID:13678237].
Active compounds
The plant contains secoiridoid glucosides (SGs) such as swertiamarin, gentiopicroside, and sweroside [PMID:31835780, 31652501, 33389948]. It also produces methoxylated xanthones (e.g., 1,5-hydroxy-3-methoxyxanthone) [PMID:11804512], phenolic acids, flavonoids [PMID:13678237, 24206732], and essential oil components including menthol, carvacrol, and tricosane [PMID:41118086]. Other isolated compounds include ursolic acid and maslinic acid [PMID:36309110].
Mechanism of action
Molecular docking suggests that swertiamarin may exert analgesic effects through binding interactions with the cyclooxygenase-2 (COX-2) protein [PMID:37948163]. The plant's essential oil inhibits $\alpha$-amylase and $\alpha$-glucosidase, which are targets for antidiabetic activity [PMID:41118086].
Clinical evidence
Evidence DGastric Damage
A 50% aqueous-ethanolic extract significantly reduced the ulcer index (by 77%) and mitigated lipid peroxidation in aspirin-induced acute gastric ulcer models in rats [PMID:21415093]
Evidence DPain
Ethanolic extract from flowering aerial parts demonstrated both peripheral analgesic activity (reducing acetic acid-induced writhing) and central antinociceptive activity (increasing basal reaction time in hot plate tests) in rats [PMID:37948163]
Evidence DDiabetes (Oxidative Stress)
Methanol extract of aerial parts protected red blood cells from glyco-oxidative stress in streptozotocin-induced diabetic rats [PMID:28323046]
Evidence DBacterial/Fungal Infections
Methanol extracts showed appreciative antibacterial and strong antifungal activity in vitro [PMID:24206732]; essential oil impeded the proliferation of Gram-positive bacteria more efficiently than Gram-negative bacteria [PMID:41118086]
Safety & adverse effects
The plant produces cytotoxic secondary metabolites, and its presence should be carefully monitored [PMID:36685651]. Specific compounds like Erythraeaxanthone II have demonstrated potent cytotoxic activity against human breast cancer cell lines in vitro [PMID:36309110].
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), focusing on phytochemical characterization and pharmacological potential. There are no human clinical trials provided in the source material.
PubMed sources
1.PMID: 33396285 (2020) — Somatic Embryogenesis in Centaurium erythraea Rafn-Current Status and Perspectives: A Review. · Plants (Basel, Switzerland)
2.PMID: 36685651 (2023) — The complete plastome of Centaurium erythraea subsp. majus (Hoffmanns. & Link) M.Laínz (Gentianaceae), the first chloroplast genome belonging to the Centaurium genus. · Mitochondrial DNA. Part B, Resources
3.PMID: 33940085 (2021) — Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn. · Journal of ethnopharmacology
4.PMID: 31835780 (2019) — Secoiridoids Metabolism Response to Wounding in Common Centaury (Centaurium erythraea Rafn) Leaves. · Plants (Basel, Switzerland)
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Role of Sodium Nitroprusside on Potential Mitigation of Salt Stress in Centaury (Centaurium erythraea Rafn) Shoots Grown In Vitro.
· Life (Basel, Switzerland)
6.PMID: 34579403 (2021) — The Arabinogalactan Protein Family of Centaurium erythraea Rafn. · Plants (Basel, Switzerland)
7.PMID: 39769294 (2024) — Transcriptome and Gene Expression Analysis Revealed CeNA1: A Potential New Marker for Somatic Embryogenesis in Common Centaury (Centaurium erythraea Rafn.). · International journal of molecular sciences
8.PMID: 35463410 (2022) — Xanthone Biosynthetic Pathway in Plants: A Review. · Frontiers in plant science
9.PMID: 11804512 (2002) — Methoxylated xanthones in the quality control of small centaury (Centaurium erythraea) flowering tops. · Journal of agricultural and food chemistry
10.PMID: 21415093 (2011) — Gastroprotective effect of small centaury (Centaurium erythraea L) on aspirin-induced gastric damage in rats. · Toxicology and industrial health
11.PMID: 35812935 (2022) — Functional Characterization of Genes Coding for Novel β-D-Glucosidases Involved in the Initial Step of Secoiridoid Glucosides Catabolism in Centaurium erythraea Rafn. · Frontiers in plant science
13.PMID: 34728697 (2021) — Phytohormone profiles in non-transformed and AtCKX transgenic centaury (Centaurium erythraea Rafn) shoots and roots in response to salinity stress in vitro. · Scientific reports
14.PMID: 39250970 (2024) — Expanding the boundaries in the face of global warming: A lesson from genetic and ecological niche studies of Centaurium erythraea in Europe. · The Science of the total environment
15.PMID: 37023241 (2022) — Organ-specific and genotype-dependent constitutive biosynthesis of secoiridoid glucosides in Centaurium erythraea Rafn, and its elicitation with methyl jasmonate. · Phytochemistry
16.PMID: 22503159 (2012) — Metal contents in Centaurium erythraea and its biometry at various levels of environmental pollution. · Ecotoxicology and environmental safety
17.PMID: 37948163 (2024) — Analgesic effect of Centaurium erythraea and molecular docking investigation of the major component swertiamarin. · Natural product research
18.PMID: 13678237 (2003) — Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). · Phytomedicine : international journal of phytotherapy and phytopharmacology
20.PMID: 31244878 (2019) — Somatic Embryogenesis in the Family Gentianaceae and Its Biotechnological Application. · Frontiers in plant science
21.PMID: 39568459 (2024) — Dynamic changes of endogenous phytohormones and carbohydrates during spontaneous morphogenesis of Centaurium erythraea Rafn. · Frontiers in plant science
22.PMID: 27297624 (2017) — News from Tartary: an ethnopharmacological approach to drug and therapeutic discovery. · British journal of clinical pharmacology
23.PMID: 30959140 (2019) — A review of Algerian medicinal plants used in the treatment of diabetes. · Journal of ethnopharmacology
24.PMID: 36309110 (2023) — Isolation and cytotoxic activities of undescribed iridoid and xanthone glycosides from Centaurium erythraea Rafn. (Gentianaceae). · Phytochemistry
25.PMID: 28323046 (2017) — Centaurium erythraea methanol extract protects red blood cells from oxidative damage in streptozotocin-induced diabetic rats. · Journal of ethnopharmacology
26.PMID: 37200270 (2023) — Nuclear analytical techniques used to study the trace element content of Centaurium erythraea Rafn, a medicinal plant species from sites with different pollution loads in Lower Silesia (SW Poland). · PloS one
27.PMID: 33389948 (2020) — Development of a New Approach for Standardization of the Herb Centaurium erythraea Rafn. by High Performance Liquid Chromatography. · Turkish journal of pharmaceutical sciences
28.PMID: 24206732 (2014) — Centauries as underestimated food additives: antioxidant and antimicrobial potential. · Food chemistry
29.PMID: 41118086 (2025) — Biological activities of Centaurium erythraea and its main chemotypes: menthol, carvacrol, and tricosane. · AMB Express