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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Chaenomeles speciosa is an edible medicinal plant from the Rosaceae family traditionally used in China to treat various ailments [PMID:38062238, PMID:30622618].
Background
Chaenomeles plants, including C. speciosa, are deciduous spiny shrubs in the Rosaceae family found and cultivated worldwide, with China serving as a primary origin and distribution hub [PMID:38062238, PMID:28895387].
Traditional uses
Traditionally used in China to treat rheumatism, cholera, dysentery, enteritis, beriberi, scurvy [PMID:38062238, PMID:24649061], anemia, gout, and cardiovascular diseases [PMID:28895387].
Active compounds
The fruit contains a diversity of phytochemicals including phenolics, flavonoids, terpenoids, organic acids, phenylpropanoids, benzoic acid derivatives, biphenyls, oxylipins, alkaloids, and vitamin C [PMID:38062238, PMID:30622618, PMID:28895387]. Specific identified compounds include chlorogenic acid, neo-chlorogenic acid, rutin, quercetin, ent-Epicatechin, and mairin [PMID:38892026, PMID:37178981]. It also contains polysaccharides and lignin-carbohydrate complexes [PMID:38998935, PMID:36336153].
Mechanism of action
C. speciosa fruit extracts may lower uric acid by inhibiting xanthine oxidase (XOD) and regulating protein expression of URAT1, GLUT9, OAT1, and OAT3 in the kidneys [PMID:38393010, PMID:39339463]. Butylchlorogenate from C. speciosa may alleviate ulcerative colitis by suppressing NLRP3 inflammasome activation and remodeling intestinal homeostasis [PMID:41005055]. Polysaccharides may act via the MAPK pathway to reduce pro-inflammatory cytokines [PMID:35401173].
Clinical evidence
Evidence DHyperuricemia
Total fruit extract (CSFTE) reduced serum uric acid, creatinine, and blood urea nitrogen levels in rats [PMID:38393010]
Evidence DRheumatoid Arthritis/Joint Inflammation
Polysaccharides demonstrated analgesic and anti-arthritic activity, reducing paw edema in CFA-induced rats [PMID:35401173]; network pharmacology suggests chondroprotective effects via targets like AKT1 and IL-6 [PMID:37178981]
Evidence DDepression
Fruit extract (CSFE) improved depressive-like behaviors in corticosterone-induced mice, reducing immobility in tail suspension and forced swim tests [PMID:38892026]
Evidence DUlcerative Colitis
Butylchlorogenate from C. speciosa shows potential in managing UC by suppressing NLRP3 inflammasome activation [PMID:41005055]
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D) and literature reviews (Level C), demonstrating significant pharmacological potential for anti-inflammatory, hypouricemic, and antidepressant effects, but lacks human clinical trials.
PubMed sources
1.PMID: 38062238 (2023) — Phytochemistry and pharmacology of plants in the genus Chaenomeles. · Archives of pharmacal research
2.PMID: 30622618 (2018) — Phytochemical and Pharmacological Properties of Chaenomeles speciosa: An Edible Medicinal Chinese Mugua. · Evidence-based complementary and alternative medicine : eCAM
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— Butylchlorogenate from Chaenomeles speciosa alleviates ulcerative colitis via suppressing NLRP3 inflammasome activation and remodeling intestinal homeostasis.
· Phytomedicine : international journal of phytotherapy and phytopharmacology
6.PMID: 38892026 (2024) — Antidepressant-like Effects of Chinese Quince (Chaenomeles sinensis) Fruit Based on In Vivo and Molecular Docking Studies. · International journal of molecular sciences
7.PMID: 24649061 (2014) — Chaenomeles speciosa: A review of chemistry and pharmacology. · Biomedical reports
8.PMID: 38393010 (2024) — Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats. · Metabolites
9.PMID: 36336153 (2022) — Structural variation of lignin-carbohydrate complexes (LCC) in Chinese quince (Chaenomeles sinensis) fruit as it ripens. · International journal of biological macromolecules
10.PMID: 35401173 (2022) — Analgesic and Anti-Arthritic Activities of Polysaccharides in Chaenomeles speciosa. · Frontiers in pharmacology
11.PMID: 37178981 (2023) — Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation. · Journal of ethnopharmacology
12.PMID: 39339463 (2024) — Bioassay-Guided Isolation and Identification of Xanthine Oxidase Inhibitory Constituents from the Fruits of Chaenomeles speciosa (Sweet) Nakai. · Molecules (Basel, Switzerland)