PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Consumption of 500 mL of Chaya beverage daily for 6 weeks significantly decreased serum triglyceride concentration and increased antioxidant enzyme expression in peripheral blood mononuclear cells [PMID:34368206].
Animal models show that Chaya extracts can lower blood glucose, cholesterol, and triglycerides, and improve muscle glucose uptake [PMID:41011114, PMID:31576586, PMID:22416660].
Ethanolic extracts demonstrated antiplatelet, anticoagulant, and fibrinolytic activities in vitro [PMID:37232450, PMID:34619052].
Methanol extract exerted gastro-protective activity and inhibited mean ulcer index in diclofenac-induced rat models [PMID:32276911].
Aqueous, ethanolic, methanolic, and ethyl acetate extracts have shown nephroprotective and hepatoprotective potential [PMID:33301380, PMID:24174819].
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 35097211 (2022) — The complete chloroplast genome sequence of chaya (Cnidoscolus aconitifolius) and phylogenetic analysis. · Mitochondrial DNA. Part B, Resources
- 2.PMID: 34697356 (2021) — Artificial selection optimizes clonality in chaya (Cnidoscolus aconitifolius). · Scientific reports
- 3.PMID: 37080365 (2023) — Chaya (Cnidoscolus aconitifolius (Mill.) I.M. Johnst) leaf extracts regulate mitochondrial bioenergetics and fatty acid oxidation in C2C12 myotubes and primary hepatocytes. · Journal of ethnopharmacology
- 4.PMID: 33301380 (2021) — Renal and Hepatic Disease: Cnidoscolus aconitifolius as Diet Therapy Proposal for Prevention and Treatment. · Journal of the American College of Nutrition
- 5.PMID: 32500956