PubMed-compiled information sheet
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Compiled from 13 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Methanolic extract of flowers produced hypotensive and vasorelaxant effects in anesthetized rats [PMID:38067429].
(-)-Epicatechin and methanolic extracts showed potent antisecretory activity against Vibrio cholera and Escherichia coli toxins in rat models [PMID:22884870, 19781621, 16174555].
Extracts showed moderate inhibitory activity (30-57%) on charcoal-gum acacia-induced hyperperistalsis in rats [PMID:20035855].
Extracts demonstrated significant activity against Entamoeba histolytica (IC50 2.5 microg/ml) and various bacterial enteropathogens including Shigella sonnei [PMID:16846708, 16005589, 28539715].
Methanolic extract of flowers showed a moderate decrease in oxidative damage in kidneys of STZ-induced hyperglycemic rats [PMID:37896035].
Evidence summary
PubMed sources
- 1.PMID: 38067429 (2023) — The Hypotensive and Vasodilatory Effects Observed in Rats Exposed to Chiranthodendron pentadactylon Larreat Flowers Can Be Attributed to Cyanidin 3-O-Glucoside. · Molecules (Basel, Switzerland)
- 2.PMID: 37896035 (2023) — Chiranthodendron pentadactylon Larreat (Sterculiaceae), a Potential Nephroprotector against Oxidative Damage Provoked by STZ-Induced Hyperglycemia in Rats. · Plants (Basel, Switzerland)
- 3.PMID: 28539715 (2017) — Antiprotozoal, Antibacterial and Antidiarrheal Properties from the Flowers of Chiranthodendron pentadactylon and Isolated Flavonoids. · Pharmacognosy magazine
- 4.PMID: 32306974 (2020) — Nuclear phylogeography of the temperate tree species Chiranthodendron pentadactylon (Malvaceae): Quaternary relicts in Mesoamerican cloud forests. · BMC evolutionary biology
- 5.PMID: 22884870