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PubMed · Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial. (2025)
PubMed · Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (<i>Citrus reticulata</i> L.), grapefruit (<i>Citrus paradisi</i> L.), lemon (<i>Citrus lemon</i> L.) and cinnamon (<i>Cinnamomum zeylanicum</i> Blume). (2021)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Cinnamomum zeylanicum (Ceylon cinnamon) is a medicinal plant used for its antioxidant, antimicrobial, and blood glucose-lowering properties [PMID: 29282046, PMID: 24817901].
Background
Cinnamomum zeylanicum, also known as 'true cinnamon' or Ceylon cinnamon, is an indigenous tree of Sri Lanka belonging to the Lauraceae family [PMID: 21929331, PMID: 24817901]. It is used globally as a spice and aromatic crop in flavoring, perfumery, and medicines [PMID: 21929331].
Traditional uses
In traditional medicine, it is considered a remedy for respiratory, digestive, and gynaecological ailments [PMID: 24148965]. It has also been used in Ayurvedic, Chinese traditional, and folk medicine as a galactogogue [PMID: 40986675].
Active compounds
The leaf oil's major component is eugenol [PMID: 21929331, PMID: 363362]. Other active compounds include (E)-cinnamaldehyde (72.98% in leaf oil), benzyl benzoate, trans-Cinnamyl acetate, polyphenols, and cinnamic acid [PMID: 36676085, PMID: 40986675].
Mechanism of action
Mechanisms for improving glycemic control include insulin-mimetic effects in-vitro [PMID: 41412108], inhibition of pancreatic α-amylase and α-glucosidase [PMID: 22671971], and modulation of hepatic glucose metabolism via changes in Pyruvate kinase (PK) and Phosphenol Pyruvate Carboxikinase (PEPCK) [PMID: 26475130]. It may also increase expression of lipolysis-related proteins (AMPK, p-ACC, CPT-1) and reduce lipid-synthesis proteins (SREBP-1c, FAS) [PMID: 38140369].
Clinical evidence
Evidence AInflammation
Pooled analysis showed significant reductions in serum C-reactive protein (CRP) [PMID: 30670254]
Evidence BType 2 Diabetes Mellitus
Clinical trials have evaluated C. zeylanicum extract for effects on HbA1c and fasting plasma glucose [PMID: 41412108, PMID: 39854533]
Evidence BHyperlipidemia
Studied for its effect on serum low-density lipoprotein cholesterol (LDL-C) and other lipid parameters [PMID: 39854533]
Safety & adverse effects
Ceylon cinnamon is generally recognized as safe (GRAS) by the U.S. FDA for use as a flavoring [PMID: 40986675]. It is generally well tolerated, though occasional bloating, dyspepsia, heartburn, and nausea have been reported [PMID: 40986675].
Pregnancy & lactation
No data exist on the safety of cinnamon in nursing mothers or infants [PMID: 40986675].
Evidence summary
Evidence ranges from high-level meta-analyses for inflammatory markers to ongoing randomized controlled trials for glycemic and lipid control; however, some systematic reviews note a historical lack of human-specific studies for C. zeylanicum compared to C. cassia [PMID: 30670254, PMID: 22671971].
PubMed sources
1.PMID: 39854533 (2025) — Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial. · PloS one
2.PMID: 40986675 (2006) — Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume). · Zeitschrift fur Naturforschung. C, Journal of biosciences
3.PMID: 41412108 (2025) — Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placebo-controlled clinical trial. · Diabetes & metabolic syndrome
4.PMID: 27771918 (2016) — Cinnamon and Chronic Diseases. · Advances in experimental medicine and biology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review.
· Drug and chemical toxicology
6.PMID: 24817901 (2014) — Cinnamon: a multifaceted medicinal plant. · Evidence-based complementary and alternative medicine : eCAM
7.PMID: 34408544 (2021) — Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats. · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
8.PMID: 32357577 (2020) — Cinnamon (Cinnamomum zeylanicum) Oil as a Potential Alternative to Antibiotics in Poultry. · Antibiotics (Basel, Switzerland)
9.PMID: 36676085 (2023) — Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. · Life (Basel, Switzerland)
10.PMID: 28962661 (2017) — Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial. · Trials
11.PMID: 24148965 (2013) — Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. · BMC complementary and alternative medicine
13.PMID: 21929331 (2011) — Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. · Critical reviews in food science and nutrition
14.PMID: 39589531 (2025) — Molecular, cellular, and metabolic insights of cinnamon (Cinnamomum zeylanicum) advantages in diabetes and related complications: condiment or medication? · Naunyn-Schmiedeberg's archives of pharmacology
15.PMID: 22518078 (2012) — Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. · Pharmacognosy research
16.PMID: 38140369 (2023) — Effects of Cinnamon (Cinnamomum zeylanicum) Extract on Adipocyte Differentiation in 3T3-L1 Cells and Lipid Accumulation in Mice Fed a High-Fat Diet. · Nutrients
17.PMID: 28951761 (2017) — Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro. · Evidence-based complementary and alternative medicine : eCAM
18.PMID: 40319007 (2025) — Potential of Cinnamomum zeylanicum for metabolic syndrome management: insights from in vivo and human studies. · Journal of integrative medicine
19.PMID: 30144878 (2018) — To what extent does cinnamon administration improve the glycemic and lipid profiles? · Clinical nutrition ESPEN
20.PMID: 27618575 (2016) — Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review. · Journal of the Academy of Nutrition and Dietetics
21.PMID: 25838932 (2015) — Effect of Cinnamomum zeylanicumon on Spermatogenesis. · Iranian Red Crescent medical journal
22.PMID: 30670254 (2019) — Effect of cinnamon (Cinnamomum Zeylanicum) supplementation on serum C-reactive protein concentrations: A meta-analysis and systematic review. · Complementary therapies in medicine
23.PMID: 26475130 (2015) — The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials. · Nutrition journal
24.PMID: 363362 (1978) — Historical overview of the cinnamon industry. · CRC critical reviews in food science and nutrition
25.PMID: 40650258 (2025) — Comprehensive Phytochemical Analysis and Evaluation of Antioxidant, Antimicrobial, Cytotoxic, and Immunomodulatory Activities of Commercial Cinnamon Bark Essential Oil (Cinnamomum zeylanicum L.). · International journal of molecular sciences
26.PMID: 29282046 (2017) — Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. · BMC complementary and alternative medicine
27.PMID: 22671971 (2012) — Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. · Diabetic medicine : a journal of the British Diabetic Association
28.PMID: 32837101 (2022) — Immunity against COVID-19: Potential role of Ayush Kwath. · Journal of Ayurveda and integrative medicine