PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
A randomized, double-blind, placebo-controlled trial of 48 male participants receiving 5g of extract twice daily for eight weeks evaluated effects on 1RM and biomarkers, though the provided abstract does not state the final significance of the results [PMID:41010491].
May regulate bone metabolism by promoting osteoblast activity and inhibiting osteoclast activity [PMID:35930138].
Extract and echinacoside ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis (in vitro C2C12 cells) [PMID:41106096].
Total glycosides protect against hepatic ischemia-reperfusion injury via cAMP-mediated signaling [PMID:41564985] and mitigate chronic alcoholic liver disease [PMID:40975324]. Polysaccharides prevent alcoholic fatty liver disease by regulating lipid metabolism and gut microbiota in mice [PMID:40288152].
Polysaccharides protect against cyclophosphamide-induced POF by regulating the JAK-STAT pathway [PMID:40381819] and enhancing female germline stem cell differentiation via BMP/SMAD signaling [PMID:39938839].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 41106096 (2025) — Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 23227786 (2012) — Cistanche deserticola Y. C. Ma, "Desert ginseng": a review. · The American journal of Chinese medicine
- 3.PMID: 35930138 (2023) — Cistanche Deserticola for Regulation of Bone Metabolism: Therapeutic Potential and Molecular Mechanisms on Postmenopausal Osteoporosis. · Chinese journal of integrative medicine
- 4.PMID: 38718638 (2024) — The role of Cistanches Herba and its ingredients in improving reproductive outcomes: A comprehensive review. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 5.PMID: 36334326