PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Tangerine peel-derived exosome-like nanovesicles (TNVs) and dried tangerine peel polysaccharide (DTPP) alleviate hepatic steatosis by regulating lipid metabolism, intestinal microflora, and suppressing TLR4/MD-2-mediated inflammation [PMID:39371479, 38640721].
Tangerine peel exosome-like nanoparticles (TPELNs) mitigate intestinal inflammation in mouse models by inhibiting pro-inflammatory cytokines (Tnf-α, Il-1β) and promoting Il-10 [PMID:40764261].
Dried tangerine peel polysaccharide (DTPP) accelerates wound healing in zebrafish and db/db mouse models by recruiting anti-inflammatory M2 macrophages [PMID:39216115].
Citrus reticulata 'Chachi' polysaccharide (CRP) alleviates gastric lesions and reduces oxidative stress in mice [PMID:40647169].
Nobiletin from C. reticulata alleviates pulmonary fibrosis in mice by inhibiting the PI3K/AKT pathway [PMID:40354836].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 39371479 (2024) — Tangerine Peel-Derived Exosome-Like Nanovesicles Alleviate Hepatic Steatosis Induced by Type 2 Diabetes: Evidenced by Regulating Lipid Metabolism and Intestinal Microflora. · International journal of nanomedicine
- 2.PMID: 29976894 (2018) — Biological Activities and Safety of Citrus spp. Essential Oils. · International journal of molecular sciences
- 3.PMID: 33909955 (2021) — Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume). · Zeitschrift fur Naturforschung. C, Journal of biosciences
- 4.PMID: 40764261 (2025) — Tangerine Peel Exosome-like Nanoparticles (TPELNs) Mitigate Intestinal Inflammation via Gut Microbiome Remodeling and Immune Modulation. · Journal of agricultural and food chemistry
- 5.PMID: 40313566