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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Coleus aromaticus (also known as Coleus amboinicus or Plectranthus amboinicus) is a perennial herb from the Lamiaceae family used traditionally for respiratory, skin, and digestive ailments [PMID:38321896, PMID:27043511].
Background
A semi-succulent perennial species native to Southeast Asia and Africa, commonly found in tropical and warm regions of Africa, Asia, and Australia [PMID:41590623, PMID:38321896, PMID:42266885]. It is also known as Indian borage, Cuban oregano, and Mexican mint [PMID:41590623, PMID:42266885].
Traditional uses
Folk medicine employs the herb to address asthma, headaches, skin disorders, coughs, constipation, colds, and fevers [PMID:38321896, PMID:27043511]. In Indonesia, it is used as a traditional galactogogue known as torbangun or bangun-bangun [PMID:30000934].
Active compounds
Major components include thymol and carvacrol [PMID:27765960, PMID:42266885]. Phenolic components include rosmarinic acid and chlorogenic acid [PMID:27765960, PMID:34068950]. Other identified phytochemicals include phenolics, terpenoids, phenolic acids, flavonoids, flavones, tannins, monoterpenoids, diterpenoids, triterpenoids, sesquiterpenoids, esters, alcohols, and aldehydes [PMID:38321896, PMID:27043511].
Mechanism of action
In antibacterial activity against P. aeruginosa and S. aureus, leaf extracts decreased catalase activity, leading to an imbalance in reactive oxygen species (ROS) and subsequent lipid peroxidation [PMID:37375543]. In liver cancer HepG2 cells, ethanolic leaf extract impeded viability by escalating ROS production and repressing the JAK/STAT cascade [PMID:35945689].
Clinical evidence
Evidence ABreast milk volume
A meta-analysis indicated that torbangun supplementation may increase breastmilk volume, though effect on infant weight gain is uncertain [PMID:30000934].
Evidence BAppetite
A ready-to-drink beverage of the herb significantly reduced plasma leptin levels and improved appetite ratings in human volunteers [PMID:24800669].
Evidence DCalcium oxalate stones
Water extract of leaves (0.5 g/kg and 1.0 g/kg) was effective in reducing the deposition of calcium oxalate in male albino rats [PMID:22556997].
Evidence DDiuresis
Water extract of leaves produced diuresis and significantly increased urine output and electrolyte concentration in rats [PMID:22557102, PMID:24948861].
Evidence DCancer (In Vitro)
Ethanolic extracts showed anticancer activity against hepatocellular carcinoma (HepG2), oral cancer (CAL 27), breast cancer (MCF-7), and lung cancer (A549) cell lines [PMID:35945689, PMID:42064131, PMID:39108647, PMID:41304998].
Evidence D
Pregnancy & lactation
Used traditionally as a galactogogue in Indonesia; however, no data exist on the excretion of components into breastmilk or the safety and efficacy in nursing mothers or infants [PMID:30000934].
Evidence summary
The evidence consists primarily of in vitro studies, animal models (rats), and a few human trials. While there is strong evidence for its phytochemical profile and in vitro biological activity (antibacterial, anticancer), robust clinical trials in humans are lacking.
PubMed sources
1.PMID: 30000934 (2006) — Coleus Amboinicus Lour. Leaf Extract as an Antioxidant in Sepsis. · Medical archives (Sarajevo, Bosnia and Herzegovina)
2.PMID: 40430526 (2025) — Plectranthus amboinicus: A Systematic Review of Traditional Uses, Phytochemical Properties, and Therapeutic Applications. · Pharmaceuticals (Basel, Switzerland)
3.PMID: 38321896 (2024) — Traditional Uses, Phytochemistry, and Pharmacological Activities of Coleus amboinicus: A Comprehensive Review. · Current pharmaceutical design
4.PMID: 24948861 (2014) — Comparative pharmacognosy of Pashanbhed. · Journal of Ayurveda and integrative medicine
5.PMID: 27765960 (2016) — Coleus aromaticus: a therapeutic herb with multiple potentials.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Extracts and essential oils exhibit significant antimicrobial activity against Gram-positive and Gram-negative bacteria and antifungal properties against dermatophytes and A. flavus [PMID:40430526, PMID:37890759].
7.PMID: 34051200 (2021) — Synthesis and characterization of TiO2 NPs by aqueous leaf extract of Coleus aromaticus and assess their antibacterial, larvicidal, and anticancer potential. · Environmental research
8.PMID: 22556997 (2000) — Antiurolithiatic activity of coleus Aromaticus Benth. In Rats. · Ancient science of life
9.PMID: 41590623 (2025) — Multi-Analytical Insight into the Non-Volatile Phytochemical Composition of Coleus aromaticus (Roxb.) Benth. · Metabolites
10.PMID: 35945689 (2022) — Ethanolic extract of Coleus aromaticus leaves impedes the proliferation and instigates apoptotic cell death in liver cancer HepG2 cells through repressing JAK/STAT cascade. · Journal of food biochemistry
11.PMID: 24800669 (2014) — Beverage from Coleus aromaticus reduces leptin levels and improves appetite rating in human volunteers. · Nutrition (Burbank, Los Angeles County, Calif.)
12.PMID: 42266885 (2026) — Nutritional Composition, Therapeutic Benefits, and Functional Food Potential of Coleus amboinicus: A Comprehensive Review. · Food science & nutrition
13.PMID: 36974541 (2023) — Anticancer Effect of Plectranthus Amboinicus and Glycyrrhiza Glabra on Oral Cancer Cell Line: An Invitro Experimental Study. · Asian Pacific journal of cancer prevention : APJCP
14.PMID: 37890759 (2023) — Insights into the antimicrobial efficacy of Coleus aromaticus essential oil against food-borne microbes: Biochemical and molecular simulation approaches. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
15.PMID: 30889692 (2019) — Biological synergy of greener gold nanoparticles by using Coleus aromaticus leaf extract. · Materials science & engineering. C, Materials for biological applications
16.PMID: 38571817 (2024) — Evaluation of Free Radical Scavenging and Antimicrobial Activity of Coleus amboinicus-Mediated Iron Oxide Nanoparticles. · Cureus
17.PMID: 41304998 (2025) — Coleus aromaticus Benth.-A Plant with Strong Anticancer and Antioxidant Potential In Vitro. · Pharmaceuticals (Basel, Switzerland)
18.PMID: 42064131 (2026) — Comparative in vitro study of Coleus amboinicus and paclitaxel on oral cancer cells. · Journal of oral and maxillofacial pathology : JOMFP
19.PMID: 37375543 (2023) — Evaluation of the Effect of Plectranthus amboinicus L. Leaf Extracts on the Bacterial Antioxidant System and Cell Membrane Integrity of Pseudomonas aeruginosa PA01 and Staphylococcus aureus NCTC8325. · Pathogens (Basel, Switzerland)
20.PMID: 39108647 (2024) — Untargeted LC/HRMS Metabolomics Analysis and Anticancer Activity Assay on MCF-7 and A549 Cells from Coleus amboinicus Lour Leaf Extract. · Iranian journal of pharmaceutical research : IJPR
21.PMID: 22557102 (2003) — Diuretic activity of coleus aromaticus benth on rats. · Ancient science of life
22.PMID: 41773042 (2026) — Chromium toxicity in Coleus amboinicus Lour.: morphological, physiological, and ultrastructural changes. · International journal of phytoremediation
23.PMID: 34068950 (2021) — Phytochemical Profile and Antioxidant Activities of Coleus amboinicus Lour. Cultivated in Indonesia and Poland. · Molecules (Basel, Switzerland)
24.PMID: 36334834 (2023) — Antibacterial, antifungal, antidiabetic, and antioxidant activities potential of Coleus aromaticus synthesized titanium dioxide nanoparticles. · Environmental research
25.PMID: 33816043 (2021) — Microwave-assisted solvent-free extraction of essential oil from Coleus aromaticus: anti-phytopathogenic potential for fruit post-harvesting. · 3 Biotech
26.PMID: 36874339 (2023) — In Silico Molecular Docking Studies of Phytocompounds From Coleus Amboinicus Against Glucokinase. · Cureus