PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Kinkeliba tablets (2 x 200 mg/day) and brew (10 g leaves/day) showed significant effectiveness in reducing systolic and diastolic blood pressure in noncomplicated hypertensive patients [PMID:32948827, PMID:29311704].
Aqueous leaf extract (100 mg/kg) produced significant hypoglycaemic and antidiabetic activity in rats comparable to glibenclamide [PMID:20219661]; in mice, it lowered plasma glucose levels in a dose-dependent manner [PMID:29567217].
Vitexin and isovitexin-rich extract significantly alleviated skin inflammation and barrier dysfunction in vitro and in vivo [PMID:36838778].
Ethanolic extract (EECM) significantly improved clinical parameters and prevented colon shortening in murine models of chronic and acute DSS-induced colitis [PMID:42123767, PMID:41373462].
Hydroalcoholic extract showed nephroprotective effects against cisplatin-induced and nicotinamide-streptozotocin induced diabetic nephropathy in rats [PMID:31146106, PMID:32673708].
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 32948827 (2021) — Hypertension treatment with Combretum micranthum or Hibiscus sabdariffa, as decoction or tablet: a randomized clinical trial. · Journal of human hypertension
- 2.PMID: 38353648 (2024) — Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology. · Chemistry & biodiversity
- 3.PMID: 36838778 (2023) — Kinkéliba (Combretum micranthum) Leaf Extract Alleviates Skin Inflammation: In Vitro and In Vivo Study. · Molecules (Basel, Switzerland)
- 4.PMID: 29567217 (2018) — Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities. · Journal of food and drug analysis
- 5.PMID: 42123767 (2026)