PubMed-compiled information sheet
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Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Convolvulus arvensis, also known as field bindweed, is a worldwide problem weed [PMID:7495531] that has been used in traditional phytotherapy [PMID:36556503].
Background
Convolvulus arvensis (field bindweed) is a member of the Convolvulaceae family [PMID:36556503] and is described as a troublesome perennial weed found among many important crops globally [PMID:30764333].
Traditional uses
It has a long history in traditional medicine [PMID:38486187] and is traditionally used to treat inflammation, skin ulcers, and wounds [PMID:36467883].
Active compounds
The plant contains tropane alkaloids including pseudotropine (the major alkaloid), tropine, and tropinone, as well as pyrrolidine alkaloids such as cuscohygrine and hygrine [PMID:7495531]. Essential oils from the leaves are rich in cuprenne (34%), thymol (20%), himachalene (16%), and longifolene (10%) [PMID:36556503]. Other identified components include resin glycosides (arvensic acids E-J) [PMID:31181918] and phenolic compounds [PMID:36467883].
Clinical evidence
Evidence DBacterial and fungal infections
Essential oils of C. arvensis exhibited antimicrobial power against pathogenic bacteria (E. coli, K. pneumoniae, S. pneumoniae, and S. aureus) and fungi (A. niger, C. albicans, and A. flavus) [PMID:36556503].
Evidence DInflammation and Cancer
Nano-encapsulated extracts were tested for anti-inflammatory, anti-cancer, and anti-bacterial activity [PMID:38486187].
Safety & adverse effects
In mice, exclusive feeding of C. arvensis led to death or euthanasia after 4-7 days, with findings of severe gastritis with ulceration/erosions and severe hepatic necrosis [PMID:8592835]. Low doses in mice caused mild multifocal gastritis and hepatitis [PMID:8592835]. In horses, grazing on pastures overrun by C. arvensis was associated with colic, weight loss, intestinal fibrosis, and vascular sclerosis of the small intestine; pseudotropine is suggested as a possible causative agent for the intestinal fibrosis [PMID:7495531].
Evidence summary
The available evidence consists primarily of phytochemical analyses, in vitro antimicrobial studies, and animal toxicity reports (D). There are no human clinical trials provided.
PubMed sources
- 1.PMID: 8592835 (1995) — Toxicity of field bindweed (Convolvulus arvensis) to mice. · Veterinary and human toxicology
- 2.PMID: 30764333 (2009) — First Report of Leaf Anthracnose Caused by Phomopsis convolvuli on Field Bindweed in Turkey. · Plant disease
- 3.PMID: 7495531 (1995) — Tropane alkaloids and toxicity of Convolvulus arvensis. · Phytochemistry
- 4.PMID: 38486187 (2024) — Phytoconstituent analysis, anti-inflammatory, antimicrobial and anticancer effects of nano encapsulated Convolvulus arvensis L. extracts. · BMC complementary medicine and therapies
- 5.PMID: 31181918 (2019) — Glycosidic Acids with Unusual Aglycone Units from Convolvulus arvensis.