PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 28 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
In an open prospective trial of 41 subjects, a dry concentrated bark extract significantly reduced fasting glucose, postprandial glucose, and HbA1c (from 7.49% to 6.82%) over six months [PMID:24678614].
Oral administration of H. latiflora extract or pure coutareagenin significantly reduced blood glucose levels in streptozotocin-induced diabetic rats [PMID:10719614, PMID:17575991, PMID:9272239].
Aqueous extracts from stem-barks and leaves demonstrated gastroprotective activity in an ethanol-induced gastric injury model in rats [PMID:23183088].
Ethyl acetate extracts of the stem bark suppressed total parasitemia and schizont numbers in mice infected with Plasmodium berghei [PMID:17067158].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 23183088 (2013) — Gastroprotective effect of Hintonia latiflora and Hintonia standleyana aqueous extracts and compounds. · Journal of ethnopharmacology
- 2.PMID: 23398496 (2013) — Mexican antidiabetic herbs: valuable sources of inhibitors of α-glucosidases. · Journal of natural products
- 3.PMID: 24412552 (2014) — Phenological and geographical influence in the concentration of selected bioactive 4-phenylcoumarins and chlorogenic acid in Hintonia latiflora leaves. · Journal of ethnopharmacology
- 4.PMID: 25442266 (2014) — The vasodilating effect of a Hintonia latiflora extract with antidiabetic action. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 5.PMID: 29988415 (2018)