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CS
Not CommonAI-summarized
Coriandrum Sativum Herb
Coriandrum sativum
digestive carminative across all world folk medicines
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Coriandrum sativum is a widely used culinary spice and medicinal herb recognized for its antioxidant, anti-inflammatory, and neuroprotective properties [PMID:29433220, PMID:35011441].
Background
Coriandrum sativum, also known as coriander or cilantro, is an annual herb belonging to the Apiaceae family [PMID:34745916, PMID:35279837]. It is native to Mediterranean regions and is cultivated globally for its edible leaves, stems, and fruits [PMID:34745916, PMID:35279837].
Traditional uses
Traditional uses include treating digestive problems, flatulence, diarrhea, colic, blepharitis, scabies, aphthous stomatitis, laryngitis, headache, palpitation, joint pain, rheumatoid arthritis, and as a carminative [PMID:34745916, PMID:35279837, PMID:39719783].
Active compounds
The seeds contain a volatile oil primarily composed of linalool and 1,8-cineole [PMID:30000851]. Other bioactive constituents include polyphenols, terpenes, flavonoids, phenylpropenes, isocoumarins, phytosterols, fatty acids (such as petroselinic acid), and specific aldehydes like (E)-2-dodecenal in the leaves [PMID:23281145, PMID:35279837, PMID:37513187, PMID:31311306].
Mechanism of action
Coriander exhibits antioxidant properties that protect against neurodegenerative diseases and metabolic syndrome [PMID:29433220]. Its compounds may interact with gamma-aminobutyric acid, 5-hydroxytryptamine, and N-methyl-D-aspartate receptors [PMID:37513187]. Specifically, (E)-2-dodecenal acts as a potent activator of KCNQ potassium channels [PMID:31311306]. In cardiovascular contexts, it may increase vasodilator factors (PGI2, NO, and eNOS) and downregulate NHE3 mRNA expression in the kidney and small intestine [PMID:35315647].
Clinical evidence
Evidence DHypertension (HFSD-induced)
Oral administration (1.0 or 2.0 g/kg bw) effectively attenuated elevation of systolic, diastolic, and mean arterial pressure in rats [PMID:35315647]
Evidence DParkinson's Disease (Mouse models)
Coriander leaves (30 and 100 mg/kg) ameliorated motor deficits and dopaminergic neuron loss in both brain-first and gut-first models [PMID:40972938]
Evidence DSeizures (PTZ-induced)
The compound (E)-2-dodecenal from cilantro leaves delayed pentylene tetrazole-induced seizures [PMID:31311306]
Evidence DRenal Malformation (Zebrafish model)
Pretreatment with coriander leaf aqueous extract mitigated kidney malformations induced by aristolochic acid [PMID:38613516]
Safety & adverse effects
Coriander is generally recognized as safe (GRAS) as a food by the U.S. FDA [PMID:30000851]. However, reports of allergic reactions, photosensitivity, contact dermatitis, and anaphylaxis following ingestion have occurred [PMID:30000851, PMID:23176891].
Pregnancy & lactation
Coriander is purported to be a galactogogue to increase milk supply, but no scientifically valid clinical trials support this use [PMID:30000851]. One case report noted that excessive use of a 10% aqueous extract possibly caused endocrine disruption in a nursing mother [PMID:30000851].
Evidence summary
The majority of evidence is based on review articles (Level C) and in vivo animal or in vitro models (Level D). There is a lack of high-level clinical trial data (Level A or B) in humans.
PubMed sources
1.PMID: 30000851 (2006) — Coriander (Coriandrum sativum L.) and its bioactive constituents. · Fitoterapia
2.PMID: 29433220 (2018) — Coriander (Coriandrum sativum): A promising functional food toward the well-being. · Food research international (Ottawa, Ont.)
3.PMID: 37241925 (2023) — Coriander (Coriandrum sativum) Polyphenols and Their Nutraceutical Value against Obesity and Metabolic Syndrome. · Molecules (Basel, Switzerland)
4.PMID: 35080667 (2022) — Agri-biotechnology of coriander (Coriandrum sativum L.): an inclusive appraisal. · Applied microbiology and biotechnology
5.PMID: 37513187 (2023) — Coriandrum sativum and Its Utility in Psychiatric Disorders.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 23281145 (2013) — Coriander (Coriandrum sativum L.): a potential source of high-value components for functional foods and nutraceuticals--a review. · Phytotherapy research : PTR
7.PMID: 35279837 (2022) — Ethnobotanical and phytochemical aspects of the edible herb Coriandrum sativum L. · Journal of food science
8.PMID: 40972938 (2026) — Coriander (Coriandrum sativum L. leaves) improves brain and gut pathology in mouse models of brain-first and gut-first Parkinson's disease. · The Journal of nutritional biochemistry
9.PMID: 30827604 (2019) — Phytochemical and bioactive profile of Coriandrum sativum L. · Food chemistry
10.PMID: 38540919 (2024) — Coriander (Coriandrum sativum L.) from Alentejo (South Portugal)-Ethnobotany and Potential Industrial Use. · Foods (Basel, Switzerland)
11.PMID: 34745916 (2021) — Neuroprotective effects of Coriandrum sativum and its constituent, linalool: A review. · Avicenna journal of phytomedicine
12.PMID: 30401772 (2018) — The Transferable Resistome of Produce. · mBio
13.PMID: 35011441 (2021) — Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits. · Molecules (Basel, Switzerland)
14.PMID: 38102554 (2023) — Physiological responses of coriander (Coriandrum sativum L.) to exogenous 2,4-epibrassinolide at different concentrations. · BMC plant biology
15.PMID: 19032971 (2009) — Safety assessment of coriander (Coriandrum sativum L.) essential oil as a food ingredient. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
17.PMID: 35634386 (2022) — Changes in Functional Compounds, Volatiles, and Antioxidant Properties of Culinary Herb Coriander Leaves (Coriandrum sativum) Stored Under Red and Blue LED Light for Different Storage Times. · Frontiers in nutrition
19.PMID: 35315647 (2022) — Protective Effect of Coriander (Coriandrum sativum L.) on High-Fructose and High-Salt Diet-Induced Hypertension: Relevant to Improvement of Renal and Intestinal Function. · Journal of agricultural and food chemistry
20.PMID: 12520125 (2003) — Water-soluble constituents of coriander. · Chemical & pharmaceutical bulletin
21.PMID: 32318724 (2020) — Cold Atmospheric Plasma Jet Inactivates Cryptosporidium parvum Oocysts on Cilantro. · Journal of food protection
22.PMID: 39719783 (2025) — Coriander: A holistic outlook on its chemistry and pharmacology. · Food chemistry
23.PMID: 31958249 (2020) — A Description of the Possible Etiology of the Cilantro Yellow Blotch Disease. · Plant disease
24.PMID: 27807783 (2017) — Assessment of uptake and phytotoxicity of cyanobacterial extracts containing microcystins or cylindrospermopsin on parsley (Petroselinum crispum L.) and coriander (Coriandrum sativum L). · Environmental science and pollution research international
25.PMID: 35449437 (2022) — Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway. · Scientific reports
26.PMID: 30646494 (2019) — Phytotoxic and Genotoxic Effects of Copper Nanoparticles in Coriander (Coriandrum sativum-Apiaceae). · Plants (Basel, Switzerland)
27.PMID: 23176891 (2012) — Anaphylaxis following cilantro ingestion. · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
28.PMID: 31311306 (2019) — Cilantro leaf harbors a potent potassium channel-activating anticonvulsant. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology