PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Demonstrated significant hypoglycemic activity in various in vitro and in vivo models, including reduction of blood glucose in STZ-induced diabetic mice and dexamethasone-induced hyperglycemic rats [PMID:39648154, PMID:26854130, PMID:20814523, PMID:18814491].
Aqueous and ethanolic stem extracts, as well as lupeol and stigmasterol, significantly lowered the deposition of calcium and oxalate in the kidneys of albino rats [PMID:22298189, PMID:22545945].
Ethanolic extract (IPP) mitigated body mass gain, adiposity, fasting glucose levels, and steatosis in a murine model [PMID:42161228].
Methanolic extract and isolated $\beta$-amyrin showed significant anti-inflammatory effects by inhibiting paw edema in rat models [PMID:25300965].
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 24600198 (2014) — A review on Insulin plant (Costus igneus Nak). · Pharmacognosy reviews
- 2.PMID: 37750223 (2024) — Costus igneus, 'the Insulin plant' causing hypoglycaemia: Two case reports. · Tropical doctor
- 3.PMID: 20814523 (2010) — Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia. · International journal of Ayurveda research
- 4.PMID: 39648154 (2025) — Costus igneus: A Versatile Herbal Remedy for Multiple Health Conditions. · Chemistry & biodiversity
- 5.PMID: 26854130 (2016) — Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus.