This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Costus speciosus, also known as crepe ginger, is a medicinal plant native to Southeast Asia used in traditional medicine for various inflammatory and metabolic conditions [PMID:27515456, PMID:26593213].
Background
Costus speciosus (Koen ex. Retz.) Sm. is an ornamental plant from the Costaceae family native to Southeast Asia, specifically found in India, Sri Lanka, Indonesia, and Malaysia [PMID:27515456, PMID:26593213].
Traditional uses
It is used in traditional medicine to treat inflammation, rheumatism, bronchitis, fever, headache, asthma, flatulence, constipation, helminthiasis, leprosy, skin diseases, hiccough, anemia, burning sensation on urination [PMID:26593213], and 'khadar' or paresthesia in Islamic Traditional Medicine [PMID:26561077]. It also has a long history in Indian Ayurvedic medicine [PMID:40435094].
Active compounds
Bioactive ingredients include alkaloids, flavonoids, glycosides, phenols, saponins, sterols, sesquiterpenes [PMID:27515456], diosgenin [PMID:34581038], raffinose [PMID:29458019], and 22-ketocholesteryl palmitate [PMID:28480734]. Metabolic profiling of rhizomes also identified methyl protogracillin, dioscin, caffeic acid, and trehalose [PMID:28814124].
Mechanism of action
Anticancer activity is attributed to the up-regulation of apoptotic molecules (p53, p21, p27, caspases, ROS) and down-regulation of anti-apoptotic agents (Akt, Bcl2, NFKB, STAT3, JAK, MMPs, actin, surviving, vimentin) [PMID:27515456]. Raffinose modulates PPARs/SREBP1c to attenuate lipid synthesis and improves insulin sensitivity via the IRβ/PI3K/Akt pathway [PMID:29458019].
Clinical evidence
Evidence CCancer
Bioactive compounds exhibit cytotoxic effects against breast, ovarian, and uterine cancers by inducing apoptosis and regulating the cell cycle [PMID:40435094].
Evidence DInflammation
Sesquiterpenes from rhizomes demonstrate anti-inflammatory activity by affecting levels of IL-6, IL-1β, TNF-α, and COX-2 [PMID:26593213].
Evidence DPolycystic Ovary Syndrome (PCOS)
In female rats, extract ameliorated phenotypes of letrozole-induced PCOS [PMID:41983838].
Evidence DDiabetes-induced Prostate Changes
Gold nanoparticles of C. speciosus ameliorated structural changes in the prostate of diabetic rats by mediating pro-inflammatory cytokines IL-6, IL-1β, and TNF-α [PMID:35164292].
Evidence DOxidative Damage (Zearalenone)
Extract protected rats against zearalenone-induced oxidative damage, genotoxicity, and cytotoxicity via modulation of Nrf2 and iNOS [PMID:35597521].
Evidence D
Safety & adverse effects
General risks associated with herbal products include potential contamination with heavy metals or toxic chemicals, which can lead to acute hepatic or renal failure [PMID:28152355]. Specific safety data for C. speciosus is limited, and further research is required to ensure the safety of its extracts [PMID:40435094].
Evidence summary
The evidence consists primarily of in vitro studies, animal models (rats/mice), and review articles. There are no human clinical trials provided in the abstracts.
PubMed sources
1.PMID: 27515456 (2016) — Possible Anticancer Mechanisms of Some Costus speciosus Active Ingredients Concerning Drug Discovery. · Current drug discovery technologies
2.PMID: 34581038 (2021) — [Research on anti-tumor natural product diosgenin]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
3.PMID: 26593213 (2015) — Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes. · Journal of ethnopharmacology
4.PMID: 40435094 (2025) — Exploring the anticancer potential of Costus speciosus: a comprehensive review. · Brazilian journal of biology = Revista brasleira de biologia
5.PMID: 28152355 (2017) — What risks do herbal products pose to the Australian community?
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Ethanolic rhizome extract increased spontaneous phasic contractions in rat myometrium, an effect abolished by L-type calcium channel or MLCK inhibition [PMID:21566246].
· The Medical journal of Australia
6.PMID: 21566246 (2011) — The effects of wild ginger (Costus speciosus (Koen) Smith) rhizome extract and diosgenin on rat uterine contractions. · Reproductive sciences (Thousand Oaks, Calif.)
7.PMID: 35597521 (2022) — Costus speciosus extract protects against the oxidative damage of zearalenone via modulation of inflammatory cytokines, Nrf2 and iNOS gene expression in rats. · Toxicon : official journal of the International Society on Toxinology
8.PMID: 35164292 (2022) — Nanoparticles of Costus speciosus Ameliorate Diabetes-Induced Structural Changes in Rat Prostate through Mediating the Pro-Inflammatory Cytokines IL 6, IL1β and TNF-α. · Molecules (Basel, Switzerland)
9.PMID: 28814124 (2018) — Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS. · Natural product research
10.PMID: 41983838 (2026) — The fortunate amelioration of Costus speciosus on phenotypes of letrozole-induced polycystic ovary syndrome in female rats. · Brazilian journal of biology = Revista brasleira de biologia
11.PMID: 29458019 (2018) — Raffinose from Costus speciosus attenuates lipid synthesis through modulation of PPARs/SREBP1c and improves insulin sensitivity through PI3K/AKT. · Chemico-biological interactions
12.PMID: 26561077 (2016) — Paresthesia: A Review of Its Definition, Etiology and Treatments in View of the Traditional Medicine. · Current pharmaceutical design
13.PMID: 28480734 (2018) — A new oxo-sterol derivative from the rhizomes of Costus speciosus. · Natural product research