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PubMed · Cyclopia maculata and Cyclopia subternata (honeybush tea) inhibits adipogenesis in 3T3-L1 pre-adipocytes. (2013)
PubMed · Analysis of the Differentially Expressed Proteins and Metabolic Pathways of Honeybush (<i>Cyclopia subternata</i>) in Response to Water Deficit Stress. (2023)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Cyclopia subternata is a South African shrub used to produce honeybush tea, recognized for its rich polyphenol content and antioxidant properties [PMID:15315375, PMID:37299160].
Background
Cyclopia subternata is one of several endemic South African shrub species used to brew honeybush tea [PMID:15315375, PMID:35033263]. It is characterized by a pleasant flavor, low tannin content, and the absence of caffeine [PMID:15315375, PMID:19032980].
Traditional uses
Since the 19th century, honeybush tea has been consumed to treat various medical ailments [PMID:23428403]. It has been used as a tonic for colds, influenza, catarrh, and pulmonic tuberculosis, and is noted for alleviating menopausal symptoms in women [PMID:15315375]. It is also used in traditional medicine to relieve pain [PMID:26243020].
Active compounds
Major compounds include the flavonoid phloretin-3',5'-di-C-glucoside [PMID:23428403], xanthones such as mangiferin and isomangiferin [PMID:15315375, PMID:19791506, PMID:19272608], and flavanones including hesperidin, narirutin, and eriocitrin [PMID:15315375, PMID:19791506]. Other identified constituents include pinitol, shikimic acid, p-coumaric acid, 4-glucosyltyrosol, epigallocatechin gallate, the isoflavone orobol, flavones luteolin, 5-deoxyluteolin, and scolymoside [PMID:15315375].
Mechanism of action
Honeybush extracts exhibit antioxidant and anti-inflammatory activities [PMID:19032980, PMID:32405387]. Specific mechanisms include the inhibition of adipogenesis via decreased PPARγ2 expression [PMID:23428403], anti-degranulation activity in allergic responses [PMID:38966058], and the suppression of HMGB1-mediated septic responses, including the inhibition of proinflammatory proteins and leukocyte adhesion [PMID:26243020]. In cancer cells, extracts may induce cell death via autophagy and ATP depletion [PMID:39139978].
Clinical evidence
Evidence DObesity (In vitro/Animal)
Hot water extracts of C. subternata inhibit adipogenesis and intracellular triglyceride accumulation in 3T3-L1 pre-adipocytes [PMID:23428403].
Evidence DUV-induced skin damage (Animal)
Topical application of honeybush extracts reduced signs of sunburn (erythema, peeling, hardening) and reduced epidermal hyperplasia and COX-2 induction in SKH-1 mice [PMID:21435898].
Evidence DAllergy (Animal)
Extracts significantly suppressed anaphylactic reaction-induced body temperature decline and inhibited antigen-antibody-induced degranulation in a murine model [PMID:38966058].
Evidence DSepsis (In vitro/Animal)
Active compounds vicenin-2 and scolymoside inhibited lipopolysaccharide-induced release of HMGB1 and suppressed septic responses in HUVECs and mice [PMID:26243020].
Evidence DCancer (In vitro)
C. subternata extracts reduced cell viability and inhibited proliferation in human liver (HepG2) and colon (HT-29) cancer cells [PMID:39139978]. A specific extract (SM6Met) showed synergistic inhibition of MCF7 breast cancer cell proliferation when combined with tamoxifen [PMID:36210845].
Safety & adverse effects
No adverse effects of honeybush consumption as tisanes have been reported [PMID:16927447].
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant antioxidant, anti-inflammatory, and photoprotective properties. There are no reported human clinical trials.
PubMed sources
1.PMID: 27618035 (2016) — Polyphenols and Sunburn. · International journal of molecular sciences
2.PMID: 23428403 (2013) — Cyclopia maculata and Cyclopia subternata (honeybush tea) inhibits adipogenesis in 3T3-L1 pre-adipocytes. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 15315375 (2004) — Phenolic metabolites from honeybush tea (Cyclopia subternata). · Journal of agricultural and food chemistry
4.PMID: 37299160 (2023) — Analysis of the Differentially Expressed Proteins and Metabolic Pathways of Honeybush (Cyclopia subternata) in Response to Water Deficit Stress. · Plants (Basel, Switzerland)
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— Biocontrol of Fusarium Species Utilizing Indigenous Rooibos and Honeybush Extracts.
· Microbiology spectrum
6.PMID: 32405387 (2020) — Effects of honeybush (Cyclopia subternata) extract on physico-chemical, oxidative and sensory traits of typical Italian salami. · Food science & nutrition
7.PMID: 35033263 (2022) — Class-modelling of overlapping classes. A two-step authentication approach. · Analytica chimica acta
8.PMID: 19032980 (2009) — Honeybush (Cyclopia sp.) - a rich source of compounds with high antimutagenic properties. · Fitoterapia
9.PMID: 32831989 (2020) — Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury. · Oxidative medicine and cellular longevity
10.PMID: 23222906 (2012) — Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity. · Molecules (Basel, Switzerland)
11.PMID: 35249566 (2022) — Entomopathogenic nematodes associated with organic honeybush (Cyclopia spp.) cultivation in South Africa. · Journal of helminthology
12.PMID: 19791506 (2009) — In vitro cultures of Cyclopia plants (honeybush) as a source of bioactive xanthones and flavanones. · Zeitschrift fur Naturforschung. C, Journal of biosciences
13.PMID: 19272608 (2009) — Isolation of isomangiferin from honeybush (Cyclopia subternata) using high-speed counter-current chromatography and high-performance liquid chromatography. · Journal of chromatography. A
14.PMID: 27367721 (2016) — Mangiferin and Cancer: Mechanisms of Action. · Nutrients
15.PMID: 22394400 (2012) — Characterization of volatiles and aroma-active compounds in honeybush (Cyclopia subternata) by GC-MS and GC-O analysis. · Journal of agricultural and food chemistry
16.PMID: 38966058 (2024) — Anti-allergic effect of Cyclopia (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen. · Bioscience of microbiota, food and health
17.PMID: 39139978 (2024) — Autophagy-induced cell death by aqueous and polyphenol-enriched extracts of honeybush (Cyclopia spp.) in liver and colon cancer cells. · Food science & nutrition
18.PMID: 28417179 (2017) — Analysis of honeybush tea (Cyclopia spp.) volatiles by comprehensive two-dimensional gas chromatography using a single-stage thermal modulator. · Analytical and bioanalytical chemistry
19.PMID: 37242784 (2023) — Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)-In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase. · Pharmaceutics
20.PMID: 26243020 (2015) — Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. · Canadian journal of physiology and pharmacology
21.PMID: 23872960 (2013) — Isoflavone production in Cyclopia subternata Vogel (honeybush) suspension cultures grown in shake flasks and stirred-tank bioreactor. · Applied microbiology and biotechnology
22.PMID: 16927447 (2007) — A review of the bioactivity of South African herbal teas: rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia). · Phytotherapy research : PTR
23.PMID: 25355549 (2014) — Anti-wrinkle effects of fermented and non-fermented Cyclopia intermedia in hairless mice. · BMC complementary and alternative medicine
24.PMID: 19916502 (2010) — Effect of pre-drying treatments and storage on color and phenolic composition of green honeybush (Cyclopia subternata) herbal tea. · Journal of agricultural and food chemistry
25.PMID: 32164369 (2020) — Pharmacological Activity of Honeybush (Cyclopia intermedia) in Boar Spermatozoa during Semen Storage and under Oxidative Stress. · Animals : an open access journal from MDPI
26.PMID: 31882089 (2020) — Development of chemical-based reference standards for rooibos and honeybush aroma lexicons. · Food research international (Ottawa, Ont.)
27.PMID: 41316849 (2025) — The Sensory and Physicochemical Properties of Honeybush Tea Depend on the Brewing Water: A Preliminary Study. · Journal of food science
28.PMID: 23880330 (2013) — Cyclopia maculata (honeybush tea) stimulates lipolysis in 3T3-L1 adipocytes. · Phytomedicine : international journal of phytotherapy and phytopharmacology
29.PMID: 36210845 (2022) — Combinatorial treatments of tamoxifen and SM6Met, an extract from Cyclopia subternata Vogel, are superior to either treatment alone in MCF-7 cells. · Frontiers in pharmacology
30.PMID: 21435898 (2011) — Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice. · Journal of photochemistry and photobiology. B, Biology