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Cydonia Oblonga Herb
Cydonia oblonga
diarrhea astringent in Middle Eastern folk medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Cydonia oblonga (quince) is a medicinal plant of the Rosaceae family recognized for its antioxidant, anti-inflammatory, and antimicrobial properties [PMID: 27445806, PMID: 35661598]. It is used in various traditional medicines to treat conditions such as diabetes, cancer, and infections [PMID: 36262168, PMID: 27445806].
Background
Cydonia oblonga, commonly known as quince, is a monotypic genus in the Rosaceae family native to the Mediterranean region [PMID: 36262168, PMID: 35661598]. It is cultivated globally and used both as a food source (processed into jams and jellies) and for its healing properties [PMID: 37049829, PMID: 35661598].
Traditional uses
Used in traditional medicine to prevent or treat ailments including cancer, diabetes, hepatitis, ulcers, respiratory infections, and urinary infections [PMID: 27445806, PMID: 36262168]. In Iranian Traditional Medicine (ITM), it is indicated for treating dysuria secondary to inflammatory disorders and urethral moisturizing layer defects [PMID: 25637157]. It is also utilized in traditional Uighur medicine [PMID: 38878943].
Active compounds
The plant is rich in secondary metabolites including phenolics, flavonoids, steroids, terpenoids, tannins, sugars, organic acids, glycosides, and megastigmane glycosides [PMID: 27445806, PMID: 38878943]. It also contains vitamins, minerals, fibers, pectin, and a polysaccharide mucilage (glucuronoxylan) extruded from the seeds [PMID: 35661598, PMID: 27445806].
Mechanism of action
Cydonia oblonga exhibits antioxidant and anti-inflammatory activities by inhibiting the secretion of cytokines such as TNF-α and IL-6 in RAW264.7 cells [PMID: 38878943]. Pulp callus extracts have been shown to inhibit oxidative stress and inflammation in injured cells by affecting the expression of genes including iNOS, IL-6, IL-1β, ikBα, and ICAM [PMID: 37237942]. It also demonstrates α-glucosidase inhibitory activity [PMID: 36559019].
Clinical evidence
Evidence BSkin Moisturizing
A 4% fresh fruit extract emulgel was evaluated in a randomized single-blind study of 13 female volunteers, showing potential for amplifying facial skin moisturizing [PMID: 38131920]
Evidence CCardiovascular Risk Factors
Review of 12 animal or in vitro studies indicates positive effects on blood pressure, diabetes, glucose metabolism, lipid profile, and thrombosis [PMID: 36262168]
Evidence DUrolithiasis (Kidney Stones)
Leaf extracts demonstrated antioxidant properties and litholytic effects on experimentally prepared calcium oxalate kidney stones in an in vitro model [PMID: 38597997]
Safety & adverse effects
Case reports indicate that allergy to quince can occur [PMID: 24176469].
Evidence summary
The majority of evidence is based on in vitro studies, animal models, and literature reviews (Level C and D), with very limited low-powered clinical data (Level B) regarding cosmetic application.
PubMed sources
1.PMID: 36262168 (2022) — Cardiovascular Effects of Cydonia oblonga Miller (Quince). · Evidence-based complementary and alternative medicine : eCAM
2.PMID: 27445806 (2016) — Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals. · Frontiers in pharmacology
3.PMID: 24176469 (2015) — Allergy to quince. · Allergologia et immunopathologia
4.PMID: 35661598 (2022) — Quince fruit Cydonia oblonga Mill nutritional composition, antioxidative properties, health benefits and consumers preferences towards some industrial quince products: A review. · Food chemistry
5.PMID: 37049829 (2023) — Changes in Physicochemical and Bioactive Properties of Quince (Cydonia oblonga Mill.) and Its Products.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
10.PMID: 38131920 (2023) — Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential. · Gels (Basel, Switzerland)
11.PMID: 37896205 (2023) — Cydonia oblonga-Seed-Mucilage-Based pH-Sensitive Graft Copolymer for Controlled Drug Delivery-In Vitro and In Vivo Evaluation. · Pharmaceutics
12.PMID: 36444248 (2022) — Effect of geographical location, processing and simulated digestion on antioxidant characteristics of quince (Cydonia oblonga). · Heliyon
13.PMID: 37929101 (2023) — Utilization of Quince (Cydonia oblonga) Peel and Exploration of Its Metabolite Profiling and Cardioprotective Potential Against Doxorubicin-Induced Cardiotoxicity in Wistar Rats. · ACS omega
14.PMID: 38878943 (2024) — Megastigmane glycosides from the traditional Uighur medicine Cydonia oblonga Mill. · Phytochemistry
15.PMID: 38876235 (2024) — Stimuli-responsive glucuronoxylan polysaccharide from quince seeds for biomedical, food packaging, and environmental applications. · International journal of biological macromolecules
16.PMID: 38597997 (2024) — Antioxidant activity and Inhibitory effects of Cydonia oblonga Miller. leaves extracts against calcium oxalate stones. · Urolithiasis
17.PMID: 37763199 (2023) — The Possibility of Using Fruit-Bearing Plants of Temperate Climate in the Treatment and Prevention of Diabetes. · Life (Basel, Switzerland)
18.PMID: 36559019 (2022) — Component Characterization, In Vitro Activities and Molecular Mechanism of Cydonia oblonga Mill. against Diabetic. · Pharmaceuticals (Basel, Switzerland)
19.PMID: 38474645 (2024) — Pulp or Peel? Comparative Analysis of the Phytochemical Content and Selected Cosmetic-Related Properties of Annona cherimola L., Diospyros kaki Thumb., Cydonia oblonga Mill. and Fortunella margarita Swingle Pulp and Peel Extracts. · Molecules (Basel, Switzerland)
20.PMID: 38247495 (2024) — Quinces (Cydonia oblonga, Chaenomeles sp., and Pseudocydonia sinensis) as Medicinal Fruits of the Rosaceae Family: Current State of Knowledge on Properties and Use. · Antioxidants (Basel, Switzerland)