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Cydonia Oblonga Herb
Cydonia oblonga
diarrhea astringent in Middle Eastern folk medicine
Cydonia oblonga (quince) exerts its medicinal effects primarily through mucilage and pectin content, which form a soothing gel-like layer over mucous membranes. This demulcent action coats and protects irritated tissues in the throat and digestive tract. The tannins provide astringent properties that help reduce inflammation and fluid secretion, making it useful for diarrhea. Quercetin contributes antioxidant and anti-inflammatory effects. Evidence level: C (preliminary evidence from traditional use and limited studies).
Does quince interact with any medications?
Currently, no established drug interactions have been documented for Cydonia oblonga. However, the mucilage content could theoretically slow absorption of oral medications if taken simultaneously. As a precaution, separate quince preparations from medications by at least 1-2 hours. Patients taking diabetes medications should monitor blood glucose, as quince seeds may affect glucose metabolism. Always consult a healthcare provider before combining herbal remedies with prescription medications. Evidence level: D (no documented interactions).
What is the recommended dosage for quince seeds?
The standard adult dosage for Cydonia oblonga seeds is 2-4 grams prepared as a mucilage tea or infusion. To prepare, soak the seeds in warm water to release the mucilaginous compounds, then strain before drinking. The fruit is commonly consumed as jams or preserves in traditional Middle Eastern and European medicine. There is insufficient clinical evidence to establish dosing for children. Consult a qualified healthcare practitioner for personalized dosing recommendations. Evidence level: C (traditional use with limited clinical data).
Is quince safe during pregnancy and breastfeeding?
Cydonia oblonga is generally considered safe during pregnancy and breastfeeding when consumed in food amounts or traditional medicinal preparations. The seeds and fruit have a long history of use in Middle Eastern and European folk medicine without reported adverse effects in pregnant populations. No teratogenic effects have been documented. However, pregnant women should avoid consuming large quantities beyond traditional food amounts and should consult their healthcare provider before using concentrated extracts. Evidence level: C (traditional use, limited clinical data).
What is quince used for in traditional medicine?
Cydonia oblonga has been used traditionally in Middle Eastern and European folk medicine primarily for treating diarrhea, where its astringent tannins help reduce intestinal secretions. The mucilage-rich seeds and fruit soothe irritated throat and respiratory passages, making it useful for coughs and sore throats. Externally, quince preparations serve as emollients for skin conditions. The fruit is commonly prepared as jams, while seeds are made into mucilaginous teas. Evidence level: C (traditional use supported by preliminary pharmacological data).
What are the side effects of taking quince?
Cydonia oblonga is well-tolerated by most individuals, with side effects being rare. The most commonly reported adverse effect is mild gastrointestinal upset, including nausea or bloating, typically occurring when consumed in large quantities. Allergic reactions are uncommon but possible, particularly in individuals sensitive to plants in the Rosaceae family. The seeds should be prepared properly as whole seeds may cause mechanical irritation. No serious adverse events have been documented in traditional use. Evidence level: C (traditional use data).
PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Cydonia oblonga (quince) is a medicinal plant of the Rosaceae family recognized for its antioxidant, anti-inflammatory, and antimicrobial properties [PMID: 27445806, PMID: 35661598]. It is used in various traditional medicines to treat conditions such as diabetes, cancer, and infections [PMID: 36262168, PMID: 27445806].
Background
Cydonia oblonga, commonly known as quince, is a monotypic genus in the Rosaceae family native to the Mediterranean region [PMID: 36262168, PMID: 35661598]. It is cultivated globally and used both as a food source (processed into jams and jellies) and for its healing properties [PMID: 37049829, PMID: 35661598].
Traditional uses
Used in traditional medicine to prevent or treat ailments including cancer, diabetes, hepatitis, ulcers, respiratory infections, and urinary infections [PMID: 27445806, PMID: 36262168]. In Iranian Traditional Medicine (ITM), it is indicated for treating dysuria secondary to inflammatory disorders and urethral moisturizing layer defects [PMID: 25637157]. It is also utilized in traditional Uighur medicine [PMID: 38878943].
Active compounds
The plant is rich in secondary metabolites including phenolics, flavonoids, steroids, terpenoids, tannins, sugars, organic acids, glycosides, and megastigmane glycosides [PMID: 27445806, PMID: 38878943]. It also contains vitamins, minerals, fibers, pectin, and a polysaccharide mucilage (glucuronoxylan) extruded from the seeds [PMID: 35661598, PMID: 27445806].
Mechanism of action
Cydonia oblonga exhibits antioxidant and anti-inflammatory activities by inhibiting the secretion of cytokines such as TNF-α and IL-6 in RAW264.7 cells [PMID: 38878943]. Pulp callus extracts have been shown to inhibit oxidative stress and inflammation in injured cells by affecting the expression of genes including iNOS, IL-6, IL-1β, ikBα, and ICAM [PMID: 37237942]. It also demonstrates α-glucosidase inhibitory activity [PMID: 36559019].
Clinical evidence
Evidence BSkin Moisturizing
A 4% fresh fruit extract emulgel was evaluated in a randomized single-blind study of 13 female volunteers, showing potential for amplifying facial skin moisturizing [PMID: 38131920]
Evidence CCardiovascular Risk Factors
Review of 12 animal or in vitro studies indicates positive effects on blood pressure, diabetes, glucose metabolism, lipid profile, and thrombosis [PMID: 36262168]
Evidence DUrolithiasis (Kidney Stones)
Leaf extracts demonstrated antioxidant properties and litholytic effects on experimentally prepared calcium oxalate kidney stones in an in vitro model [PMID: 38597997]
Safety & adverse effects
Case reports indicate that allergy to quince can occur [PMID: 24176469].
Evidence summary
The majority of evidence is based on in vitro studies, animal models, and literature reviews (Level C and D), with very limited low-powered clinical data (Level B) regarding cosmetic application.
PubMed sources
1.PMID: 36262168 (2022) — Cardiovascular Effects of Cydonia oblonga Miller (Quince). · Evidence-based complementary and alternative medicine : eCAM
2.PMID: 27445806 (2016) — Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals. · Frontiers in pharmacology
3.PMID: 24176469 (2015) — Allergy to quince. · Allergologia et immunopathologia
4.PMID: 35661598 (2022) — Quince fruit Cydonia oblonga Mill nutritional composition, antioxidative properties, health benefits and consumers preferences towards some industrial quince products: A review. · Food chemistry
5.PMID: 37049829 (2023) — Changes in Physicochemical and Bioactive Properties of Quince (Cydonia oblonga Mill.) and Its Products. · Molecules (Basel, Switzerland)
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
10.PMID: 38131920 (2023) — Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential. · Gels (Basel, Switzerland)
11.PMID: 37896205 (2023) — Cydonia oblonga-Seed-Mucilage-Based pH-Sensitive Graft Copolymer for Controlled Drug Delivery-In Vitro and In Vivo Evaluation. · Pharmaceutics
12.PMID: 36444248 (2022) — Effect of geographical location, processing and simulated digestion on antioxidant characteristics of quince (Cydonia oblonga). · Heliyon
13.PMID: 37929101 (2023) — Utilization of Quince (Cydonia oblonga) Peel and Exploration of Its Metabolite Profiling and Cardioprotective Potential Against Doxorubicin-Induced Cardiotoxicity in Wistar Rats. · ACS omega
14.PMID: 38878943 (2024) — Megastigmane glycosides from the traditional Uighur medicine Cydonia oblonga Mill. · Phytochemistry
15.PMID: 38876235 (2024) — Stimuli-responsive glucuronoxylan polysaccharide from quince seeds for biomedical, food packaging, and environmental applications. · International journal of biological macromolecules
16.PMID: 38597997 (2024) — Antioxidant activity and Inhibitory effects of Cydonia oblonga Miller. leaves extracts against calcium oxalate stones. · Urolithiasis
17.PMID: 37763199 (2023) — The Possibility of Using Fruit-Bearing Plants of Temperate Climate in the Treatment and Prevention of Diabetes. · Life (Basel, Switzerland)
18.PMID: 36559019 (2022) — Component Characterization, In Vitro Activities and Molecular Mechanism of Cydonia oblonga Mill. against Diabetic. · Pharmaceuticals (Basel, Switzerland)
19.PMID: 38474645 (2024) — Pulp or Peel? Comparative Analysis of the Phytochemical Content and Selected Cosmetic-Related Properties of Annona cherimola L., Diospyros kaki Thumb., Cydonia oblonga Mill. and Fortunella margarita Swingle Pulp and Peel Extracts. · Molecules (Basel, Switzerland)
20.PMID: 38247495 (2024) — Quinces (Cydonia oblonga, Chaenomeles sp., and Pseudocydonia sinensis) as Medicinal Fruits of the Rosaceae Family: Current State of Knowledge on Properties and Use. · Antioxidants (Basel, Switzerland)