PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Yacon syrup supplementation in humans demonstrated significant reductions in fasting insulin and HOMA-IR [PMID: 40077758]. Yacon flour use can reduce glycemia and HbA1c [PMID: 38794228]. In rats, yacon improved hepatic insulin resistance by reducing Trb3 expression [PMID: 23712282].
Yacon syrup significantly reduced LDL cholesterol in humans [PMID: 40077758]. In high-fat-diet-fed rats, yacon flour attenuated weight gain and decreased visceral fat pad weight [PMID: 30510798]. Diabetic rats showed decreased fasting plasma triacylglycerol and VLDL levels [PMID: 21907189].
Yacon syrup improved satiety and intestinal transit time in humans [PMID: 40077758]. It acts as a prebiotic, favoring the growth of health-promoting bacteria like Lactobacillus and Bifidobacterium [PMID: 27455312, PMID: 24936376].
In rats, a diet containing 1.0% yacon root extract or a synbiotic formulation significantly reduced the number of aberrant crypt foci and invasive adenocarcinomas [PMID: 22595329].
Ethanolic yacon leaf extract (YLE) was found to attenuate LPS-induced neuroinflammation in vitro and in vivo [PMID: 30149424].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 30149424 (2018) — Smallanthus sonchifolius leaf attenuates neuroinflammation. · Journal of exercise nutrition & biochemistry
- 2.PMID: 37603903 (2023) — Yacon (Smallanthus sonchifolius) and kefir improved intestinal and bone health but without symbiotic benefits in rats. · Nutrition research (New York, N.Y.)
- 3.PMID: 38794228 (2024) — Effects of Smallanthus sonchifolius Flour on Metabolic Parameters: A Systematic Review. · Pharmaceuticals (Basel, Switzerland)
- 4.PMID: 27455312 (2016) — Yacon (Smallanthus sonchifolius) as a Food Supplement: Health-Promoting Benefits of Fructooligosaccharides. · Nutrients
- 5.PMID: 38947460 (2024) — Investigating the potential of yacon (Smallanthus sonchifolius) juice in the development of organic apple-based snacks.