This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
PubMed · Polyphenols from <i>Dichrostachys cinerea</i> Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model. (2022)
PubMed · Clinical evaluation of Veerataru (Dichrostachys cinerea Linn.) in the management of Mootrakruchchhra (Dysuria). (2013)
Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Dichrostachys cinerea is a tropical leguminous shrub used in traditional medicine for inflammatory, respiratory, and urinary conditions [PMID:36080212, 21414220, 24501517].
Background
Dichrostachys cinerea (L.) Wigth & Arn. is a tropical leguminous shrub [PMID:28612173] that is widely used in ethno-medicine across Africa [PMID:21414220].
Traditional uses
Traditionally used to treat rheumatoid arthritis [PMID:36080212], bronchial asthma [PMID:25914041, 21414220], rheumatism [PMID:25914041, 21731394], dysuria (Mootrakruchchhra) [PMID:24501517], jaundice, fever, body ache, chest problems, toothache, ulcers, wounds, eye diseases, and as an aphrodisiac [PMID:21731394]. It is also used as a laxative, diuretic, and painkiller, and in the treatment of gonorrhoea, boils, oedema, gout, and veneral diseases [PMID:24991072]. In Tanzania, it is used by the Maasai for suspected malaria [PMID:30947717] and as a snakebite antivenom [PMID:36205572].
Active compounds
The plant contains polyphenols, including flavan-3-ols (such as (-)-mesquitol, oritin, (-)-festidinol, and (-)-epicatechin), proanthocyanidins, and flavone glycosides [PMID:36080212, 21706215]. Other identified compounds include meroterpene derivatives (dichrostachines A-R) [PMID:19761234], betulinic acid, glyceryl-1-hexacosanoate, 7-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, 6-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one [PMID:31360 la], and beta-amyrin glucoside [PMID:24991072]. General phytochemical screening has shown the presence of carbohydrates, proteins, glycosides, saponins, tannins, amino acids, and terpenoids [PMID:24991072].
Mechanism of action
Extracts have demonstrated the ability to inhibit protein farnesyl transferase activity [PMID:19761234] and advanced glycation end-product (AGE) formation [PMID:21706215]. Root bark extracts induce relaxation of tracheal smooth muscle [PMID:21963567].
Clinical evidence
Evidence DInflammation and Pain (Rat Model)
Polyphenol-rich fruit extracts showed analgesic, anti-inflammatory, and antioxidant effects in Freund's adjuvant-induced arthritic rats [PMID:36080212]
Evidence BDysuria
Evaluated for efficacy in the management of Mootrakruchchhra (Dysuria) [PMID:24501517]
Leaf extracts showed antibacterial activity against S. epidermidis and S. aureus [PMID:38045177, 10844173]
Evidence DCancer (In vitro)
Triterpenoid 1 (betulinic acid) and flavone 4 from bark showed cytotoxic effects against 9 cancer cell lines [PMID:31360210]
Evidence DAsthma (Animal Model)
Methanolic and aqueous-alcoholic extracts induced relaxation of guinea-pig and mouse tracheal smooth muscle [PMID:21414220, 21963567]
Safety & adverse effects
A methanolic extract of leaves did not show mortality in albino mice and rats up to a dose of 3500 mg/kg body weight [PMID:21731394].
Pregnancy & lactation
Bark extracts are traditionally used to facilitate childbirth; in vitro studies on isolated pregnant rat myometrium were conducted to investigate these properties [PMID:25914041].
Evidence summary
The evidence consists primarily of in vitro studies, animal models (rats, mice, guinea-pigs), and preliminary clinical evaluations. There is a lack of high-level human clinical trials (Meta-analyses or large-scale RCTs).
PubMed sources
1.PMID: 36080212 (2022) — Polyphenols from Dichrostachys cinerea Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model. · Molecules (Basel, Switzerland)
3.PMID: 24501517 (2013) — Clinical evaluation of Veerataru (Dichrostachys cinerea Linn.) in the management of Mootrakruchchhra (Dysuria). · Ayu
4.PMID: 25914041 (2015) — Study of pharmacological properties of the methanolic extract of Dichrostachys cinerea bark (L.) Wight et Arn (Leguminosae) in isolated myometrium from pregnant rats. · Journal of ethnopharmacology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania.
· Malaria journal
6.PMID: 21414220 (2011) — Dichrostachys cinerea (L.) Wight et Arn (Mimosaceae) hydro-alcoholic extract action on the contractility of tracheal smooth muscle isolated from guinea-pig. · BMC complementary and alternative medicine
7.PMID: 21963567 (2011) — Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K⁺ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark. · Journal of ethnopharmacology
8.PMID: 28612173 (2017) — Evaluation of the feeding value of Dichrostachys cinerea pods for fattening pigs in Cuba. · Tropical animal health and production
9.PMID: 21731394 (2011) — Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves. · Pharmacognosy research
10.PMID: 24991072 (2013) — Phytochemical analysis of ethanolic extract of Dichrostachys Cinerea W and Arn leaves by a thin layer chromatography, high performance thin layer chromatography and column chromatography. · Ancient science of life
11.PMID: 38045177 (2023) — Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics. · Heliyon
12.PMID: 19761234 (2009) — Meroterpenes from Dichrostachys cinerea inhibit protein farnesyl transferase activity. · Journal of natural products
13.PMID: 36205572 (2022) — Ethnomedicinal plants used for treatment of snakebites in Tanzania - a systematic review. · Pharmaceutical biology
14.PMID: 31360210 (2019) — Cytotoxicity of Crude Extract and Isolated Constituents of the Dichrostachys cinerea Bark towards Multifactorial Drug-Resistant Cancer Cells. · Evidence-based complementary and alternative medicine : eCAM
15.PMID: 29859076 (2018) — Antibacterial activity and in situ efficacy of Bidens pilosa Linn and Dichrostachys cinerea Wight et Arn extracts against common diarrhoea-causing waterborne bacteria. · BMC complementary and alternative medicine
16.PMID: 21706215 (2012) — New advanced glycation end-products inhibitors from Dichrostachys cinerea Wight & Arn. · Journal of natural medicines
17.PMID: 28684709 (2017) — Trypanosoma brucei Inhibition by Essential Oils from Medicinal and Aromatic Plants Traditionally Used in Cameroon (Azadirachta indica, Aframomum melegueta, Aframomum daniellii, Clausena anisata, Dichrostachys cinerea and Echinops giganteus). · International journal of environmental research and public health