PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 12 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Alkaloids from D. leptopodum demonstrated cytotoxicity against SMMC-7721 cells [PMID:24963327]. Isocorydine and its analogs inhibited the growth of HepG2, HeLa, and MGC-803 cancer cell lines [PMID:29171235]. Dendrimer-alkaloid complexes (specifically G5.NHAc-PBA-CHE and G5.NHAc-PBA-MAG) showed targeting and inhibitory effects on breast cancer MCF-7 cells [PMID:38586940].
Isocorydine exhibited potent antibacterial activity with a minimum inhibitory concentration (MIC) of 400 μg/mL [PMID:41459214].
Evidence summary
PubMed sources
- 1.PMID: 39588115 (2024) — Review: Dicranostigma leptopodum: A peculiar plant of Papaveraceae. · Open life sciences
- 2.PMID: 36460956 (2022) — Characterization of the Dicranostigma leptopodum chloroplast genome and comparative analysis within subfamily Papaveroideae. · BMC genomics
- 3.PMID: 38092109 (2024) — From genomics to metabolomics: Deciphering sanguinarine biosynthesis in Dicranostigma leptopodum. · International journal of biological macromolecules
- 4.PMID: 25330407 (2015) — Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high-performance liquid chromatography with diode array detection. · Journal of separation science
- 5.PMID: 24963327