PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Lipidic extracts and ointments (2.5% and 5%) showed wound-healing activity in rat and mice models [PMID:37866421, 31143772]. A combination ointment with Marrubium vulgare accelerated burn wound healing and showed analgesic and anti-inflammatory effects [PMID:35337087].
Methanolic extracts showed promising cytotoxic activity against human breast cancer cell lines MCF-7 and MDA-MB-468 without cytotoxicity toward normal PBMCs [PMID:35408507]. Other studies noted antiproliferative and cytotoxic properties [PMID:39599445, 34015367].
Extracts demonstrated antibacterial activity against Proteus mirabilis, Bacillus subtilis, Staphylococcus aureus, and Escherichia coli, as well as antifungal activity against Candida species and Alternaria alternata [PMID:35408507, 37866421, 37372075, 28665341].
A specific root extract fraction ('K') reduced immobility time in the forced swim test in a mouse model, showing effects comparable to paroxetine [PMID:35256610].
Methanolic extracts showed potent in vitro inhibitory activity against α-amylase and α-glucosidase and an antiglycation effect [PMID:35408507].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 21754752 (2011) — 3-(4-Chloro-phen-yl)-1-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octa-hydro-naphthalen-2-yl]prop-2-en-1-one. · Acta crystallographica. Section E, Structure reports online
- 2.PMID: 21754232 (2011) — 1-(4a,8-Dimethyl-1,2,3,4,4a,5,6,8a-octa-hydro-naphthalen-2-yl)-3-phenyl-prop-2-en-1-one. · Acta crystallographica. Section E, Structure reports online
- 3.PMID: 21522737 (2010) — 3-[4-(Dimethyl-amino)-phen-yl]-1-(4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octa-hydro-naphthalen-2-yl)prop-2-en-1-one. · Acta crystallographica. Section E, Structure reports online
- 4.PMID: 22904849 (2012) — Methyl 2-(4a,8-Dimethyl-7-oxodeca-hydro-naphthalen-2-yl)acrylate. · Acta crystallographica. Section E, Structure reports online
- 5.PMID: 22259450