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Djibouti Desert Tamarisk
Tamarix aphylla
treatment of skin conditions in Horn of Africa folk medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Tamarix aphylla is a perennial halophytic tree found in Asia, the Middle East, and Central Africa, recognized for its diverse pharmacological properties including anti-inflammatory and antimicrobial activities [PMID:35009121].
Background
Tamarix aphylla, also known as Athel tamarisk, is a drought-resistant phreatophyte that thrives in arid, hypersaline conditions [PMID:37903263, PMID:39053515]. It is characterized by its ability to excrete concentrated salt solutions and possesses robust erosion-resistant characteristics [PMID:37903263, PMID:24305989].
Traditional uses
It has been used in traditional medicine as a carminative diuretic for tuberculosis, leprosy, and hepatitis [PMID:35009121], as well as an astringent, anti-rheumatic agent, and for the treatment of fever [PMID:27517880].
Active compounds
The plant is rich in polyphenols, including phenolic acids (gallic, caffeic, p-coumaric, ferulic, ellagic, syringic, and 3-hydroxybenzoic acids) and flavonoids (kaempferol, quercetin, and isorhamnetin) [PMID:27517880, PMID:38558274]. Other identified constituents include ellagitannins, gallotannins, and gallo-ellagitannins in the galls [PMID:25987319], as well as aromatic and volatile compounds such as Benzeneselenol, Gibberellic acid, and Triaziquone [PMID:36677418].
Mechanism of action
Anti-inflammatory effects are mediated through the inhibition of intracellular reactive oxygen species (ROS) production, nitric oxide (NO) generation, and T-cell proliferation [PMID:32630007], and by modulating TNF-α, IL-1β, COX-2, and NO levels [PMID:38273280]. Gastroprotective effects are associated with the modulation of the MAPK signaling pathway and the PTGS2 gene [PMID:38728332].
Clinical evidence
Evidence DInflammation
T. aphylla demonstrated anti-inflammatory activity in Wistar albino rats by reducing levels of TNF-α, IL-1β, COX-2, and NO in inflamed paw tissue [PMID:38273280].
Evidence DGastric Ulcers
Leaves crude extract ameliorated indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway and alleviating oxidative stress [PMID:38728332].
Evidence DHepatotoxicity
Ethanolic extract of T. aphylla showed hepato-protective ability against sodium arsenite-induced liver injury in rats [PMID:36190635].
Evidence DAcid-Burn Wounds
A nanoemulsion cream containing T. aphylla extract was evaluated for efficacy in healing acid-burn wounds in rabbits [PMID:36676658].
Evidence DFungal Infections
Water and ethanolic extracts showed fungicidal properties against Macrophomina phaseolina, Curvularia spicifera, and Fusarium spp. [PMID:36677418].
Evidence D
Safety & adverse effects
An acute oral toxicity assay in Wistar rats using graded doses up to 4 g/kg indicated that T. aphylla is generally safe [PMID:38273280].
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant potential for anti-inflammatory, antioxidant, and antimicrobial applications, though human clinical trials are lacking.
PubMed sources
1.PMID: 35009121 (2021) — Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review. · Plants (Basel, Switzerland)
2.PMID: 36677418 (2023) — The Antifungal Properties of Tamarix aphylla Extract against Some Plant Pathogenic Fungi. · Microorganisms
3.PMID: 24305989 (2013) — Active anti-erosion protection strategy in tamarisk (Tamarix aphylla). · Scientific reports
4.PMID: 37903263 (2023) — Harvesting of aerial humidity with natural hygroscopic salt excretions. · Proceedings of the National Academy of Sciences of the United States of America
5.PMID: 22908641 (2012) — Enhanced dissipation of polycyclic aromatic hydrocarbons in the rhizosphere of the Athel tamarisk (Tamarix aphylla L. Karst.) grown in saline-alkaline soils of the former lake Texcoco.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Ethanolic extract was explored for its activity against the SpaP virulence gene in multidrug-resistant Streptococcus mutans [PMID:37575558].
Evidence DCancer Cell Proliferation
Aqueous and ethanol extracts exhibited dose-dependent cytotoxicity, with potent effects specifically predicted against MCF-7 breast adenocarcinoma cells [PMID:30034503].
· International journal of phytoremediation
6.PMID: 37575558 (2023) — Assessment of the Antivirulence Potential of Tamarix aphylla Ethanolic Extract against Multidrug-Resistant Streptococcus mutans Isolated from Iraqi Patients. · TheScientificWorldJournal
7.PMID: 32630007 (2020) — Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study. · Molecules (Basel, Switzerland)
8.PMID: 39053515 (2024) — Surviving the desert's grasp: Decipherment phreatophyte Tamarix aphylla (L.) Karst. Adaptive strategies for arid resilience. · Plant science : an international journal of experimental plant biology
9.PMID: 38558274 (2024) — Assessing the Chemical Profile and Biological Potentials of Tamarix aphylla (L.) H.Karst. and Tamarix senegalensis DC. by In Vitro, In Silico, and Network Methodologies. · Applied biochemistry and biotechnology
10.PMID: 38273280 (2024) — Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study. · BMC complementary medicine and therapies
11.PMID: 25987319 (2015) — Ellagitannins, gallotannins, and gallo-ellagitannins from the galls of Tamarix aphylla. · Fitoterapia
12.PMID: 27517880 (2016) — Evaluation of Antioxidant, Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia. · Chemistry & biodiversity
13.PMID: 38728332 (2024) — Tamarix aphylla derived metabolites ameliorate indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway, alleviating oxidative stress and inflammation: In vivo study supported by pharmacological network analysis. · PloS one
14.PMID: 36676658 (2022) — The Therapeutic Application of Tamarix aphylla Extract Loaded Nanoemulsion Cream for Acid-Burn Wound Healing and Skin Regeneration. · Medicina (Kaunas, Lithuania)
15.PMID: 30034503 (2018) — Potential Antiproliferative Activity and Evaluation of Essential Oil Composition of the Aerial Parts of Tamarix aphylla (L.) H.Karst.: A Wild Grown Medicinal Plant in Jordan. · Evidence-based complementary and alternative medicine : eCAM
16.PMID: 36190635 (2023) — Mechanistic insights on the possible protective role of polyphenols extracted from Tamarix aphylla aerial parts against sodium arsenite-induced hepatotoxicity in rats. · Environmental science and pollution research international