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Dwarf Elder
Sambucus ebulus
Strong laxative and emetic in European folk medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Dwarf elder (Sambucus ebulus L.) is a medicinal plant used in folk medicine for various ailments, though its use is restricted by the presence of toxic proteins [PMID:25723322, PMID:28397551].
Background
Sambucus ebulus L., known as dwarf elder, is a perennial plant characterized by long, creeping, and branched rhizomes, primarily distributed in northern, northwestern, and northeastern regions of Iran [PMID:40999650].
Traditional uses
It has been used since ancient times in folk medicine for joint pains, colds, wounds, infections, and is specifically applied in Traditional Persian Medicine for bone and joint disorders [PMID:28397551, PMID:27125590].
Active compounds
The plant contains flavonoids, lectins (such as ebulin f and SELfd), and ribosome-inactivating proteins (RIPs) [PMID:28397551, PMID:24793353, PMID:25723322]. Fruit extracts are rich in polyphenols, anthocyanins (notably cyanidin-3-O-galactoside and cyaniding-3-sambubioside), hydroxycinnamic acids, and proanthocyanidins [PMID:24793353, PMID:34834808, PMID:37240060]. Other identified compounds include neochlorogenic acid, chlorogenic acid, idaein, epicatechin, resveratrol, chrysanthemin, and the iridoid diglycoside sambuloside [PMID:4094191B, PMID:30810365].
Mechanism of action
Ribosome-inactivating proteins (RIPs) in the plant act as enzymes (E.C. 3.2.2.22) with N-glycosidase activity on the 28S rRNA subunit, which inhibits protein synthesis by arresting polypeptide chain elongation [PMID:25723322]. Fruit extracts may exert anti-inflammatory effects by reducing endoplasmic reticulum (ER) stress [PMID:40941911, PMID:34834808].
Clinical evidence
Evidence BPaederus dermatitis
A 5% S. ebulus fruit extract solution (Palemolin) was statistically more effective than a placebo in controlling burning, pain, inflammation, and accelerating healing [PMID:25276209]
Evidence BHand eczema
Topical preparation of S. ebulus leaves decreased severity and itching scores over 4 weeks, with no significant difference compared to hydrocortisone [PMID:33571040]
Evidence BKnee osteoarthritis
A pilot randomized trial evaluated the efficacy of topical S. ebulus gel versus 1% diclofenac gel for pain and function [PMID:27125590]
Evidence DImmune response (Healthy humans)
Intake of S. ebulus fruit infusion for 4 weeks resulted in a significant decrease in total protein [PMID:37240060]
Evidence DDepression (Animal model)
Methanolic extracts of S. ebulus fruit showed significant dose-dependent antidepressant activity in mice, with 1200 mg/kg performing better than imipramine in forced swimming and tail suspension tests [PMID:25491608]
Evidence D
Safety & adverse effects
The plant is toxic, and its use as food is restricted due to this toxicity [PMID:25723322]. Specifically, the lectin ebulin f displays toxicity upon oral ingestion [PMID:24793353]. However, heat treatment (boiling water bath for five minutes) can sensitize these lectins to pepsin digestion, potentially eliminating toxicity [PMID:24793353].
Evidence summary
Evidence is mixed, consisting primarily of in vitro and animal studies (Level D) and a few small-scale randomized controlled trials (Level B) for topical dermatological and joint applications. Safety is a significant concern due to inherent toxicity of certain proteins.
PubMed sources
1.PMID: 25723322 (2015) — Ebulin from dwarf elder (Sambucus ebulus L.): a mini-review. · Toxins
2.PMID: 28397551 (2017) — Biological Effects and Clinical Applications of Dwarf Elder ( Sambucus ebulus L): A Review. · Journal of evidence-based complementary & alternative medicine
3.PMID: 27125590 (2016) — Efficacy and short-term safety of topical Dwarf Elder (Sambucus ebulus L.) versus diclofenac for knee osteoarthritis: A randomized, double-blind, active-controlled trial. · Journal of ethnopharmacology
4.PMID: 25491608 (2014) — Antidepressant activities of Sambucus ebulus and Sambucus nigra. · European review for medical and pharmacological sciences
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Aquatic extract decreased L. major viability, lesion size, and parasite burden while increasing IFN-γ-to-IL-4 ratio and nitric oxide levels [PMID:30472741]
Evidence DTriple-negative breast cancer (In vitro/In vivo)
S. ebulus extract remarkably decreased cell proliferation and viability in TNBC models [PMID:33845752]
Evidence DHerpes simplex virus type 1 (In vitro)
Hydroalcoholic extract led to a 2.6 log10 TCID50 reduction in viral titer at 75 μg/mL [PMID:33996660]
Evidence DMRSA (In vitro)
Methanolic extracts showed antibacterial potency against clinical isolates of methicillin-resistant Staphylococcus aureus [PMID:25395702]
— Sambucus ebulus extract stimulates cellular responses in cutaneous leishmaniasis.
· Parasite immunology
6.PMID: 30810365 (2020) — A new iridoid diglycoside from Sambucus ebulus L. · Natural product research
7.PMID: 33845752 (2022) — Effects of Sambucus ebulus Extract on Cell Proliferation and Viability of Triple- Negative Breast Cancer: An In Vitro and In Vivo Study. · Anti-cancer agents in medicinal chemistry
8.PMID: 25647575 (2015) — Elderberries: a source of ribosome-inactivating proteins with lectin activity. · Molecules (Basel, Switzerland)
9.PMID: 25276209 (2014) — Treatment of Paederus Dermatitis with Sambucus ebulus Lotion. · Iranian journal of pharmaceutical research : IJPR
10.PMID: 40941911 (2025) — Modulation of Endoplasmic Reticulum Stress by Selected Polyphenols from Sambucus ebulus L. Fruit. · Plants (Basel, Switzerland)
11.PMID: 10516985 (1999) — Nutrition and dietary supplements. · Physical medicine and rehabilitation clinics of North America
12.PMID: 24793353 (2014) — Effects of short-term heating on total polyphenols, anthocyanins, antioxidant activity and lectins of different parts of dwarf elder (Sambucus ebulus L.). · Plant foods for human nutrition (Dordrecht, Netherlands)
13.PMID: 33996660 (2021) — Inhibition of herpes simplex virus type 1 infection by Sambucus ebulus extract in vitro. · Medical journal of the Islamic Republic of Iran
14.PMID: 23122129 (2013) — Differential sensitivity of D-galactose-binding lectins from fruits of dwarf elder (Sambucus ebulus L.) to a simulated gastric fluid. · Food chemistry
15.PMID: 37330943 (2023) — In Vitro and In Vivo Anti-parasitic Activity of Sambucus ebulus and Feijoa sellowiana Extracts Silver Nanoparticles on Toxoplasma gondii Tachyzoites. · Acta parasitologica
16.PMID: 23884825 (2013) — Anti-giardial activity of Sambucus ebulus. · European review for medical and pharmacological sciences
17.PMID: 40999650 (2026) — Genetic and Micromorphological Diversity in Sambucus ebulus (Adoxaceae) Populations and Their Taxonomic Significance. · Microscopy research and technique
18.PMID: 34834808 (2021) — Phytochemical Composition, Anti-Inflammatory and ER Stress-Reducing Potential of Sambucus ebulus L. Fruit Extract. · Plants (Basel, Switzerland)
19.PMID: 39057215 (2024) — Leaf and Flower Extracts from the Dwarf Elder (Sambucus ebulus): Toxicity and Repellence against Cosmopolitan Mosquito-Borne Diseases Vectors. · Insects
20.PMID: 31881758 (2019) — Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles. · Nanomaterials (Basel, Switzerland)
21.PMID: 37240060 (2023) — Sambucus ebulus (Elderberry) Fruits Modulate Inflammation and Complement System Activity in Humans. · International journal of molecular sciences
22.PMID: 33571040 (2021) — A Comparison of the Effect of Topical Preparation of Sambucus ebulus L. and Hydrocortisone on Hand Eczema: A Double-Blind Randomized Controlled Trial. · Journal of alternative and complementary medicine (New York, N.Y.)
23.PMID: 23852900 (2013) — In vitro effect of Sambucus ebulus on scolices of Hydatid cysts. · European review for medical and pharmacological sciences
24.PMID: 36565417 (2023) — Transient receptor potential channel stimulation induced oxidative stress and apoptosis in the colon of mice with colitis-associated colon cancer: modulator role of Sambucus ebulus L. · Molecular biology reports
25.PMID: 33497693 (2021) — Recombinant pebulin protein, a type 2 ribosome-inactivating protein isolated from dwarf elder (Sambucus ebulus L.) shows anticancer and antifungal activities in vitro. · International journal of biological macromolecules
26.PMID: 41977792 (2026) — Evaluation of Nutraceutical Properties of Fruits Derived from Some Wild-Growing Plant Species (Sambucus nigra L., Rubia tinctorum L., Phytolacca americana L. and Sambucus ebulus L.). · Plants (Basel, Switzerland)
27.PMID: 25395702 (2014) — Antimicrobial activity of methanolic extracts of Sambucus ebulus and Urtica dioica against clinical isolates of methicillin resistant Staphylococcus aureus. · African journal of traditional, complementary, and alternative medicines : AJTCAM