PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Ethanolic extract of I. britannica (EEIB) showed protective effects against lipid metabolism, inflammation, and oxidative stress in mice [PMID:39606269]
Flower essential oil (100 mg/kg) showed noteworthy antinociceptive effects in mice across multiple pain models [PMID:29567278]
Administration improved survival rates in mice and reduced cytokine fluctuation in the spleen [PMID:10815011]
The sesquiterpene lactone OABL reduced LPS-induced neuroinflammation in microglial cells and showed neuroprotective effects in PC12 cells [PMID:35026701]
Certain sesquiterpenoids from I. britannica flowers displayed antiproliferative potency against TNBC cells [PMID:36014473]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 35026701 (2022) — Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model. · Redox biology
- 2.PMID: 37627631 (2023) — Development and Characterization of Inula britannica Extract-Loaded Liposomes: Potential as Anti-Inflammatory Functional Food Ingredients. · Antioxidants (Basel, Switzerland)
- 3.PMID: 37454617 (2023) — Fermentation of Inula britannica using Lactobacillus plantarum SY12 increases of epigallocatechin gallate and attenuates toxicity. · Food chemistry
- 4.PMID: 39606269 (2024) — Inula britannica ameliorates alcohol-induced liver injury by modulating SIRT1-AMPK/Nrf2/NF-κB signaling pathway. · Chinese herbal medicines
- 5.PMID: 12492516