PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Alantolactone suppresses inflammation, apoptosis, and oxidative stress in cigarette smoke-induced human bronchial epithelial cells [PMID:32321531]
Elecampane root extract and alantolactone inhibit the adipogenic differentiation of 3T3-L1 cells [PMID:35897937]
A mixture of alantolactone, isoalantolactone, and alloalantolactone induces mitochondrion-related apoptosis and inhibits proliferation and migration in PANC-1 and SW1990 cells [PMID:30661396]
Inula helenium extract loaded in nanofibers showed antioxidative and anti-inflammatory activities and promoted skin wound healing in a rat model [PMID:39042854]
Dietary methanol and n-hexane extracts of elecampane rhizome increased body weight gain and decreased feed conversion ratio in broiler chickens during the finisher and entire periods [PMID:30821191]
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 32321531 (2020) — Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways. · Respiratory research
- 2.PMID: 35209195 (2022) — From Monographs to Chromatograms: The Antimicrobial Potential of Inula helenium L. (Elecampane) Naturalised in Ireland. · Molecules (Basel, Switzerland)
- 3.PMID: 35897937 (2022) — Elecampane (Inula helenium) Root Extract and Its Major Sesquiterpene Lactone, Alantolactone, Inhibit Adipogenesis of 3T3-L1 Preadipocytes. · Molecules (Basel, Switzerland)
- 4.PMID: 39376605 (2024) — Isoalantolactone: a review on its pharmacological effects. · Frontiers in pharmacology
- 5.PMID: 34134031