This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Eryngium campestre is a thorny herb of the Apiaceae family used in Mediterranean countries as food and traditional remedies [PMID:28332760]. It has demonstrated antibacterial, anti-inflammatory, and cytotoxic properties in various laboratory and animal models [PMID:40670425, PMID:16529889, PMID:28332760].
Background
Eryngium campestre is a thorny herb belonging to the Apiaceae family that grows spontaneously in dry meadows and stony pastures, particularly on calcareous substrates [PMID:28332760]. It is found in regions including Central Italy, Algeria, Turkey, Germany, and Spain [PMID:28332760, PMID:31311207, PMID:16529889, PMID:18564089, PMID:24146454].
Traditional uses
In Mediterranean countries, the plant has been used as food or as traditional remedies to treat various ailments [PMID:28332760]. It is used as a folk remedy worldwide for the treatment of various inflammatory disorders [PMID:16529889].
Active compounds
The plant contains essential oils rich in sesquiterpene hydrocarbons, specifically germacrene D (major compound), allo-aromadendrene, β-elemene, spathulenol, ledol [PMID:28332760], and campestrolide (a 17-membered ring lactone) [PMID:31311207, PMID:30544816]. Other identified constituents include triterpene saponins from the roots [PMID:16872157, PMID:16204991], coumarin derivatives such as aegelinol benzoate, agasyllin, and grandivittin [PMID:17342596], as well as flavonoids, alkaloids, tannins, phenols, terpenoids, steroids, and coumarins [PMID:40670425].
Mechanism of action
Aqueous extracts of E. campestre have been shown to reduce levels of pro-inflammatory cytokines interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) in rat serum [PMID:31473993]. In murine endothelial cells, extracts inhibited cytokine-stimulated, iNOS-dependent synthesis of nitric oxide [PMID:15800391].
Clinical evidence
Evidence DInflammation (Animal/In Vitro)
Ethanol extracts from aerial parts or roots showed apparent anti-inflammatory and antinociceptive activity in mice [PMID:16529889].
Evidence DCalcium Oxalate Kidney Stones (Animal)
Aqueous extracts from aerial parts reduced IL-1β and IL-6 levels in rats with ethylene glycol-induced kidney stones [PMID:31473993].
Evidence DBacterial Infections (In Vitro)
Egyptian ecotype shoot (ethyl acetate fraction) and root (petroleum ether fraction) extracts inhibited the growth of nine tested bacterial species [PMID:40670425].
Evidence DCancer (In Vitro)
Essential oils showed cytotoxic effects on human malignant melanoma (A375), breast adenocarcinoma (MDA-MB 231), and colon carcinoma (HCT116) cells [PMID:28332760].
Evidence DTrypanosoma/Leishmania (In Vitro)
Hexanic extracts showed moderate antitrypanosomal and antileishmanial activities; the compound campestrolide was very active against Trypanosoma [PMID:30544816].
Safety & adverse effects
A hexanic extract of E. campestre displayed cytotoxicity against human normal fibroblasts (IC50 = 4.4 μg/mL) [PMID:30544816]. Some sources categorize it as a meadow weed that can be toxic to animals [PMID:32390852].
Evidence summary
The current evidence is based entirely on in vitro studies (cell lines, bacterial cultures) and in vivo animal models (rats, mice). There are no human clinical trials available in the provided data.
PubMed sources
1.PMID: 28332760 (2017) — Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy. · Chemistry & biodiversity
2.PMID: 31311207 (2019) — Essential Oil of Algerian Eryngium campestre: Chemical Variability and Evaluation of Biological Activities. · Molecules (Basel, Switzerland)
3.PMID: 16872157 (2006) — Triterpene saponins from Eryngium campestre. · Journal of natural products
4.PMID: 40670425 (2025) — Evaluation of the antibacterial potential in shoot and root extracts of Eryngium campestre with emphasis on Egyptian ecotype. · Scientific reports
5.PMID: 31473993 (2019) — The Effects of Aqueous Extract of Eryngium Campestre on Ethylene Glycol-Induced Calcium Oxalate Kidney Stone in Rats.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 40351368 (2025) — The Effect of Chitosan Edible Coating Containing Nanoemulsion of Eryngium campestre Essential Oil on the Quality of Ostrich Meat During Storage in Refrigerator. · Food science & nutrition
7.PMID: 30544816 (2018) — Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian Eryngium campestre. · Molecules (Basel, Switzerland)
8.PMID: 16204991 (2005) — Two new triterpene saponins from Eryngium campestre. · Chemical & pharmaceutical bulletin
9.PMID: 16529889 (2006) — Comparative evaluation of the anti-inflammatory and antinociceptive activity of Turkish Eryngium species. · Journal of ethnopharmacology
10.PMID: 32390852 (2020) — Turning Meadow Weeds Into Valuable Species for the Romanian Ethnomedicine While Complying With the Environmentally Friendly Farming Requirements of the European Union's Common Agricultural Policy. · Frontiers in pharmacology
11.PMID: 18564089 (2008) — Genetic variation of Eryngium campestre L. (Apiaceae) in Central Europe. · Molecular ecology
13.PMID: 33925367 (2021) — Evaluation of the Antioxidant, Anti-Inflammatory and Cytoprotective Activities of Halophyte Extracts against Mycotoxin Intoxication. · Toxins
14.PMID: 26740759 (2014) — Antibacterial and antitumour activities of some plants grown in Turkey. · Biotechnology, biotechnological equipment
15.PMID: 32749577 (2021) — Biosynthesis of Novel Silver Nanoparticles Using Eryngium thyrsoideum Boiss Extract and Comparison of their Antidiabetic Activity with Chemical Synthesized Silver Nanoparticles in Diabetic Rats. · Biological trace element research
16.PMID: 33973578 (2021) — Nematicidal activity of aqueous tinctures of plants against larvae of the nematode Strongyloides papillosus. · Tropical biomedicine
17.PMID: 21404428 (2011) — Phytochemical constituents and inhibitory activity towards methicillin-resistant Staphylococcus aureus strains of Eryngium species (Apiaceae). · Chemistry & biodiversity
18.PMID: 24146454 (2013) — Traditional knowledge of medicinal plants in the Serra de Mariola Natural Park, South-Eastern Spain. · African journal of traditional, complementary, and alternative medicines : AJTCAM
19.PMID: 15800391 (2005) — Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
20.PMID: 15800392 (2005) — Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society