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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 24 PubMed articles · model: gemma4:31b
Summary
Fagonia arabica is a medicinal plant from the Zygophyllaceae family found in desert regions, recognized for its thrombolytic, antioxidant, and antimicrobial properties [PMID:34554901, PMID:40751117].
Background
Fagonia arabica (also known as Dhamasa) is a medicinal plant widely distributed in desert areas including Saudi Arabia, Pakistan, India, South Africa, and Egypt [PMID:34554901, PMID:40751117].
Traditional uses
It is traditionally used in Ayurvedic and Unani medicine as a natural blood purifier to aid in dissolving blood clots and reducing the risk of cardiovascular events and brain hemorrhage [PMID:41306891]. Other traditional uses include treating sore mouth, smallpox, vertigo, stomatitis, and conditions related to hematological, neurological, endocrinological, and inflammatory systems [PMID:34554901]. It is also used as a folk remedy for anti-inflammatory, analgesic, and antipyretic effects [PMID:19520135, PMID:24250453].
Active compounds
The plant contains a wide range of bioactive constituents including saponins (specifically triterpenoid saponins), flavonoids, glycosides, tannins, steroids, terpenoids, diterpenes, phenols, alkaloids, and phenolic compounds such as chlorogenic acid, gallic acid, and catechin [PMID:34554901, PMID:40751117, PMID:8728716, PMID:17338564, PMID:39939326].
Mechanism of action
Fagonia arabica demonstrates thrombolytic activity by antagonizing thrombin-induced release of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in human umbilical vein endothelial cells [PMID:27419084]. It also exhibits antioxidant activity by scavenging free radicals (ABTS.+) and modulating cellular antioxidant enzymes such as SOD, CAT, GSH-Px, and GSH-R [PMID:19520135, PMID:24250453].
Clinical evidence
Evidence DThrombosis/Blood Clots
In vitro studies show significant clot lytic potential, with some extracts showing patterns similar to streptokinase [PMID:21427565, PMID:17986325, PMID:27833372].
Evidence DCoagulation
Aqueous extracts demonstrate potent anticoagulant activity, with some fractions showing significant results compared to heparin [PMID:23814169].
Evidence DBacterial Infections
Extracts showed significant inhibitory actions against Staphylococcus epidermidis and other bacterial strains [PMID:40751117, PMID:37533430].
Evidence DMale and Female Fertility
Ethanol extracts of aerial parts were found to enhance fertility in both male and female Wistar rats [PMID:35642406].
Evidence DCancer
Extracts showed anti-proliferative activity against HeLa and HepG2 cell lines in vitro [PMID:39764423].
Evidence DGastric Diseases (H. pylori)
Safety & adverse effects
Acute oral toxicity tests were performed as part of a polyherbal antidiabetic formulation, though specific adverse effects for F. arabica alone are not detailed in the provided abstracts [PMID:40679012].
Evidence summary
The current evidence is primarily based on in vitro studies, animal models (rats/mice), and literature reviews. There is a lack of human clinical trials (RCTs) to establish clinical efficacy and safety in humans.
PubMed sources
1.PMID: 34554901 (2022) — Fagonia arabica L.: A Review of its Phytochemistry, Pharmacology and Traditional Uses. · Combinatorial chemistry & high throughput screening
2.PMID: 17986325 (2007) — Effect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis. · BMC complementary and alternative medicine
3.PMID: 27833372 (2015) — In vitro thrombolytic activity of Dhamasa (Fagonia arabica Linn.), Kushta (Saussurea lappa Decne.), and Guduchi (Tinospora cordifolia Thunb.). · Ayu
4.PMID: 41306891 (2025) — Liposomal formulation of Fagonia arabica L. enhances antithrombotic efficacy: phytochemical, pharmacological, and computational investigations. · RSC advances
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
F. arabica exhibited significant anti-urease inhibitory activity [PMID:40089925].
— Insight into the biological activities of Fagonia Arabica L. and its phytochemical constituents.
· AMB Express
6.PMID: 8728716 (1996) — Saponins from Fagonia arabica. · Phytochemistry
7.PMID: 17338564 (2007) — Sulfated triterpene derivatives from Fagonia arabica. · Journal of natural products
8.PMID: 39764423 (2025) — Growth suppressing effect of Fagonia arabica extracts on cancerous cell line. · Cytotechnology
9.PMID: 24250453 (2012) — Antioxidant Potential of Fagonia arabica against the Chemical Ischemia-Induced in PC12 Cells. · Iranian journal of pharmaceutical research : IJPR
10.PMID: 39939326 (2025) — UPLC-qTOF-MS/MS profiling of phenolic compounds in Fagonia arabica L. and evaluation of their cholinesterase inhibition potential through in-vitro and in-silico approaches. · Scientific reports
11.PMID: 21427565 (2011) — In-vitro clot lytic potential of Fagonia arabica: a comparative study of two methods. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
12.PMID: 18069237 (2007) — Phytochemical and molluscicidal investigations of Fagonia arabica. · Zeitschrift fur Naturforschung. C, Journal of biosciences
13.PMID: 37533430 (2023) — Antibacterial Activity of Economically Important Medicinal Plants in Pakistan Against Different Bacterial Strains. · Bioinformatics and biology insights
14.PMID: 35642406 (2022) — Phytochemical analysis and fertility enhancement effects of aerial parts of Fagonia arabica in male and female rats. · Pakistan journal of pharmaceutical sciences
15.PMID: 23814169 (2014) — Effect of aqueous extract and fractions of Fagonia arabica on in vitro anticoagulant activity. · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
16.PMID: 27419084 (2016) — Effect of Fagonia arabica on thrombin induced release of t-PA and complex of PAI-1 tPA in cultured HUVE cells. · Journal of traditional and complementary medicine
17.PMID: 40679012 (2025) — Formulation and evaluation of safe and effective polyherbal antidiabetic drug. · Pakistan journal of pharmaceutical sciences
18.PMID: 19520135 (2009) — Protection of PC12 cells from chemical ischemia induced oxidative stress by Fagonia arabica. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
19.PMID: 40089925 (2025) — In vitro urease inhibition screening of some edible and medicinal herbs to combat Helicobacter pylori related gastric diseases. · Pakistan journal of pharmaceutical sciences
20.PMID: 21814440 (2010) — Synergistic activity of Fagonia arabica and Heteropneustes fossilis extracts against myocardial, cerebral infarction, and embolism disorder in mice. · Journal of pharmacy & bioallied sciences