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Ferula Assafoetida Herb
Ferula assa-foetida
digestive antispasmodic in Unani-Ayurvedic medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Ferula assa-foetida is an oleo-gum-resin obtained from the roots of the Ferula assa-foetida plant, traditionally used for various medicinal purposes and as a culinary spice [PMID:31629871, PMID:21130854].
Background
Asafoetida is an oleo-gum-resin exudate from the roots of Ferula assa-foetida L. and other Ferula species, distributed across central Asia and the Mediterranean area [PMID:31629871, PMID:25657791].
Traditional uses
Traditionally used to treat asthma, gastrointestinal disorders, intestinal parasites [PMID:31629871, PMID:21130854], and is considered in Iranian traditional medicine to be sedative, analgesic, carminative, antispasmodic, diuretic, antihelmintic, emmenagogue, and expectorant [PMID:25657791]. It has also been used for hysteria and other nervous disorders [PMID:33456735].
Active compounds
Main compounds include monoterpenes, sulfide compounds, polyphenols [PMID:37034135], sugars, sesquiterpene coumarins (such as farnesiferol C, conferone, badrakemin, feslol, isosamarcandin, and samarcandin), and polysulfides [PMID:21130854, PMID:28948835, PMID:26134757]. Specific identified metabolites include foetisulfide C, assafoetidnol A, gumosin, and flabellilobin (A/B) [PMID:36738001].
Mechanism of action
Evidence suggests activities including antioxidant, anti-inflammatory, and anti-apoptotic effects [PMID:28725631, PMID:33456735]. It may modulate the microbiome-gut-brain axis to alleviate dyspepsia symptoms [PMID:41054174] and exhibit antinociceptive effects in thermal and acetic acid-induced tests [PMID:25657791].
Clinical evidence
Evidence BFunctional Dyspepsia
A self-emulsifying hydrogel formulation (250 mg/d) significantly improved symptoms of early satiety, bloating, and heartburn [PMID:41054174]
Evidence BPolycystic Ovary Syndrome (PCOS)
Administration of 100 mg twice daily for 3 months significantly decreased the number of ovarian follicles compared to placebo [PMID:37655000]
Evidence DCancer
Organosulfides from the gum showed significant in-vitro inhibition of SKOV3 and A549 cancer cell growth [PMID:33960249]; in-vivo studies in mice showed antitumor effects against 4T1 breast cancer cells [PMID:28690055]
Evidence DDiabetes/Nephropathy
In rat models, 50 mg/kg oral dose reduced glucose, cholesterol, and HbA1c, and decreased serum creatinine and urea [PMID:38910415]; ethanolic extract (150-250 mg/kg) improved serum glucose and insulin levels [PMID:35474229]
Evidence DPain/Inflammation
Demonstrated antinociceptive effects in mice [PMID:25657791] and anti-inflammatory effects against TNF-α-stimulated HUVECs in vitro [PMID:36091666]
Evidence D
Safety & adverse effects
In rodents, acute oral doses up to 5 g/kg and subchronic doses of 250 mg/kg for 28 days showed no significant changes in body weight or hematological parameters, though mild liver thrombosis and glomerular tuft atrophy were noted [PMID:27047139]. Asafoetida oil is considered an irritant to skin and eyes, and a dermal and respiratory sensitiser [PMID:36570350].
Evidence summary
Evidence is primarily based on in-vitro studies and animal models (Level D), with limited clinical evidence from small-scale RCTs (Level B) regarding PCOS and functional dyspepsia.
PubMed sources
1.PMID: 31629871 (2019) — NMR-based metabolomic study of asafoetida. · Fitoterapia
2.PMID: 37034135 (2023) — Anticancer potential of Ferula assa-foetida and its constituents, a powerful plant for cancer therapy. · World journal of biological chemistry
3.PMID: 36570350 (2022) — Safety and efficacy of a feed additive consisting of an essential oil from the gum resin of Ferula assa-foetida L. (asafoetida oil) for use in dogs and cats (FEFANA asbl). · EFSA journal. European Food Safety Authority
4.PMID: 21130854 (2011) — Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-a review. · Journal of ethnopharmacology
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Showed anticonvulsant effects in chemical and amygdala-kindled rats [PMID:25210675] and ameliorated peripheral neuropathy in mice [PMID:24709312]
Evidence DViral Infections
In vitro activity against HSV-1 and HSV-2 showed significant inhibition of infectivity [PMID:39737349]
— Proteomic and metabolomic insights into seed germination of Ferula assa-foetida.
· Journal of proteomics
6.PMID: 36482498 (2022) — Therapeutic effect of Ferula assa-foetida oleo-gum resin in rats with letrozole-induced polycystic ovary syndrome. · Clinical and experimental reproductive medicine
7.PMID: 25657791 (2014) — Antinociceptive effect of Ferula assa-foetida oleo-gum-resin in mice. · Research in pharmaceutical sciences
8.PMID: 28725631 (2017) — Biological activities and medicinal properties of Asafoetida: A review. · Journal of traditional and complementary medicine
9.PMID: 28948835 (2018) — Biological activities of farnesiferol C: a review. · Journal of Asian natural products research
10.PMID: 36738001 (2023) — Comparative phytochemical analysis of Ferula assa-foetida with Ferula jaeschkeana and commercial oleo-gum resins using GC-MS and UHPLC-PDA-QTOF-IMS. · Food research international (Ottawa, Ont.)
11.PMID: 38910415 (2024) — Nephroprotective Effect of Ferula assa-foetida Oleo Gum Resin on Type 2 Diabetic Rats. · Current pharmaceutical design
12.PMID: 33456735 (2020) — Preventive Effect of Ferula asafoetida Oleo Gum Resin on Histopathology in Cuprizone-Induced Demyelination Mice. · International journal of preventive medicine
13.PMID: 30001603 (2018) — Rheological and functional properties of asafoetida gum. · International journal of biological macromolecules
14.PMID: 36091666 (2022) — Anti-Inflammatory Activity of Ferula assafoetida Oleo-Gum-Resin (Asafoetida) against TNF-α-Stimulated Human Umbilical Vein Endothelial Cells (HUVECs). · Mediators of inflammation
15.PMID: 33960249 (2022) — Purification and identification of anticancer organosulfides from Ferula assa-foetida gum: integrative analysis employing GC/GC-MS/RP-HPLC/NMR. · Natural product research
16.PMID: 39737349 (2024) — Antiviral activity of Ferula assa-feotida on HSV-1, 2 in vitro. · Iranian journal of microbiology
17.PMID: 27942173 (2016) — Effect of Ferula assa-foetida oleo-gum-resin on renal function in normal Wistar rats. · Indian journal of nephrology
18.PMID: 35474229 (2022) — Ferula assa-foetida oleo gum resin ethanolic extract alleviated the pancreatic changes and antioxidant status in streptozotocin-induced diabetic rats: A biochemical, histopathological, and ultrastructural study. · Journal of food biochemistry
19.PMID: 37655000 (2023) — "Ferula assa-foetida L" or "Foeniculum vulgare"? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded. · Avicenna journal of phytomedicine
20.PMID: 25210675 (2014) — Anticonvulsant effect of ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. · North American journal of medical sciences
21.PMID: 24709312 (2014) — Oleo gum resin of Ferula assa-foetida L. ameliorates peripheral neuropathy in mice. · Journal of ethnopharmacology
22.PMID: 27047139 (2015) — Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents. · Veterinary world
23.PMID: 24761245 (2014) — The Relaxant Effect of Seed's Essential Oil and Oleo-Gum-Resin of Ferula Assa-Foetida on Isolated Rat's Ileum. · Annals of medical and health sciences research
24.PMID: 41054174 (2025) — Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study. · Medicine
25.PMID: 26134757 (2016) — Identification of sesquiterpene coumarins of oleo-gum resin of Ferula assa-foetida L. from the Yasuj region. · Natural product research
26.PMID: 28690055 (2017) — Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice. · Journal of Ayurveda and integrative medicine
27.PMID: 30087798 (2017) — Effects of Oleo Gum Resin of Ferula assa-foetida L. on Senescence in Human Dermal Fibroblasts: - Asafoetida reverses senescence in fibroblasts. · Journal of pharmacopuncture
28.PMID: 40108916 (2026) — The Protective Effects of Ferula assa-foetida L. oleo-gum Resin on Diabetic Neuropathy in Animal Models. · Current medicinal chemistry