PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Aqueous extracts improved resistance to hypoxia, normalized orientation and exploration, promoted conditioned passive avoidance response (CPAR) retention, and increased physical performance in mice, with effects comparable to piracetam [PMID:25778665, 22448356].
Lyophilized flower infusions demonstrated antihyperalgesic and antiedematous activities in rat models of carrageenan-induced inflammation [PMID:27725238].
Standardized top flower extract significantly reduced cell proliferation, viability, migration, and in vivo tumor growth; it also synergized with Cisplatin and Pemetrexed in vitro [PMID:31399037].
Methanolic extracts of aerial parts and roots inhibited COX-1 and COX-2 activities in vitro [PMID:30291943].
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 25778665 (2015) — Nootropic effect of meadowsweet (Filipendula vulgaris) extracts. · Bulletin of experimental biology and medicine
- 2.PMID: 31399037 (2019) — Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma. · Journal of experimental & clinical cancer research : CR
- 3.PMID: 29132911 (2018) — Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. · Journal of ethnopharmacology
- 4.PMID: 27725238 (2016) — Antihyperalgesic activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench in a rat model of inflammation. · Journal of ethnopharmacology
- 5.PMID: 22448356 (2011)