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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 28 PubMed articles · model: gemma4:31b
Summary
Fo Ti Vine (Fallopia multiflora), also known as He Shou Wu, is a traditional Chinese medicinal herb used for anti-aging and various chronic conditions [PMID:31644102, 35069206], though it is strongly associated with herb-induced liver injury [PMID:31644102, 30066422].
Background
Fallopia multiflora (Thunb.) Harald, also referred to as Polygonum multiflorum, is a vine native to China [PMID:31644102, 37213683]. It is widely used in traditional Chinese medicine, particularly the root tubers [PMID:33878622, 39384802].
Traditional uses
Used for centuries to treat backache, dizziness, liver disease, constipation, and the graying of hair [PMID:31644102, 11206309], and is valued for anti-aging, liver- and kidney-tonifying effects [PMID:33062019].
Active compounds
The primary bioactive component is 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) [PMID:40244282, 35069206]. Other identified compounds include stilbenes, anthraquinones, phenolic acids, naphthalenes, flavonoids, and polysaccharides [PMID:33878622, 30711810, 29222011].
Mechanism of action
TSG is reported to alleviate oxidative stress, inflammation, and apoptosis [PMID:40244282]. Polysaccharides from the herb exhibit hydroxyl radical scavenging activity and increase serum superoxide dismutase and glutathione peroxidase activities [PMID:29222011]. Additionally, some components may inhibit fatty acid synthase (FAS) [PMID:14998716].
Clinical evidence
Evidence AAging and Age-related Diseases
TSG demonstrates comprehensive anti-aging effects, including lifespan extension, neuroprotection (Alzheimer's and Parkinson's), cardiovascular protection, reduction in bone loss, and promotion of hair regrowth [PMID:40244282].
Evidence CLiver Injury
Implicated in numerous reports of clinically apparent acute liver injury, which can be severe or fatal [PMID:31644102, 30066422].
Evidence DObesity
Tuber fleeceflower root significantly reduced body weight and food intake in rats via inhibition of fatty acid synthase [PMID:14998716].
Safety & adverse effects
The herb is associated with significant hepatotoxicity, including acute cholestatic hepatitis and hepatocellular injury [PMID:30066422, 11206309]. It is cited as one of the most common causes of Chinese herbal medicine-induced liver injury [PMID:27651817, 31644102].
Evidence summary
Strong evidence (Systematic Review/Meta-analysis) exists for the anti-aging properties of the isolated compound TSG and the herb's association with liver injury. Other pharmacological claims are based on reviews or animal models.
2.PMID: 31643904 (2012) — Attributes of Polygonum multiflorum to transfigure red biotechnology. · Applied microbiology and biotechnology
3.PMID: 33878622 (2021) — Tissue-specific metabolite profiling of Fallopia multiflora (Heshouwu) and Fallopia multiflora var. angulata by mass spectrometry imaging and laser microdissection combined with UPLC-Q/TOF-MS. · Journal of pharmaceutical and biomedical analysis
4.PMID: 30711810 (2019) — Determination of the species status of Fallopia multiflora, Fallopia multiflora var. angulata and Fallopia multiflora var. ciliinervis based on morphology, molecular phylogeny, and chemical analysis. · Journal of pharmaceutical and biomedical analysis
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Traditional Chinese Medicine Induced Liver Injury.
· Journal of clinical and translational hepatology
6.PMID: 40244282 (2025) — 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging. · International journal of molecular sciences
7.PMID: 39384802 (2024) — T2T genome assemblies of Fallopia multiflora (Heshouwu) and F. multiflora var. angulata. · Scientific data
8.PMID: 37213683 (2023) — The first chromosome-level Fallopia multiflora genome assembly provides insights into stilbene biosynthesis. · Horticulture research
9.PMID: 39041120 (2024) — [Widely targeted metabolomics reveals differential metabolites between root tuber and leaf of Fallopia multiflora]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
10.PMID: 35069206 (2021) — A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside. · Frontiers in pharmacology
11.PMID: 38350506 (2024) — Mechanistic study of the anti-excitatory amino acid toxicity of Bushen Zhichan decoction for Parkinson's disease based on the transcriptional regulation of EAAT1 by YY1. · Journal of ethnopharmacology
12.PMID: 30066422 (2019) — Clinicopathological features of He Shou Wu-induced liver injury: This ancient anti-aging therapy is not liver-friendly. · Liver international : official journal of the International Association for the Study of the Liver
13.PMID: 36561458 (2022) — Molecular identification and functional characterization of two glycosyltransferases genes from Fallopia multiflora. · Frontiers in plant science
14.PMID: 18318821 (2008) — Hepatotoxic slimming aids and other herbal hepatotoxins. · Journal of gastroenterology and hepatology
15.PMID: 33062019 (2020) — Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum. · Evidence-based complementary and alternative medicine : eCAM
16.PMID: 14998716 (2004) — Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase. · Life sciences
17.PMID: 28933127 (2016) — [Bencao literature investigation of Polygonum multiflorum (Heshouwu)]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
18.PMID: 25536637 (2015) — Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. · Annals of hepatology
19.PMID: 27651817 (2016) — Systematic Review on Chinese Herbal Medicine Induced Liver Injury. · Evidence-based complementary and alternative medicine : eCAM
20.PMID: 38087457 (2024) — Phytochemical analysis and hepatotoxicity assessment of braised Polygoni Multiflori Radix (Wen-He-Shou-Wu). · Biomedical chromatography : BMC
21.PMID: 23019899 (2012) — [Molecular authentication of Fallopia multiflora by PCR-RFLP based on the trnL-trnF analysis]. · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
22.PMID: 23633031 (2014) — Species identification of Chinese medicinal plant Fallopia multiflora (Thunb.) Haraldson by suppression subtraction hybridization. · Journal of natural medicines
23.PMID: 35692575 (2022) — Exploration on the Improvement of Cognitive Function and Inflammatory Response in Perimenopausal Patients with Mild Cognitive Impairment by Self-Prepared Ningshen Prescription. · Evidence-based complementary and alternative medicine : eCAM
24.PMID: 26130933 (2015) — Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds. · Pharmacognosy research
25.PMID: 29138972 (2018) — Stable isotope labeling and 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside biosynthetic pathway characterization in Fallopia multiflora. · Planta
26.PMID: 29222011 (2018) — Preparation, characterization and antioxidant activity of polysaccharide from Fallopia multiflora (Thunb.) Harald. · International journal of biological macromolecules
27.PMID: 11206309 (2001) — Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum. · Journal of gastroenterology and hepatology
28.PMID: 35364310 (2022) — Investigation on the mechanism of 2,3,4',5-Tetrahydroxystilbene 2-o-D-glucoside in the treatment of inflammation based on network pharmacology. · Computers in biology and medicine