PubMed-compiled information sheet
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Compiled from 12 PubMed articles · model: gemma4:31b
Summary
Citri Reticulatae Pericarpium Viride (Qing Pi) is a traditional Chinese medicinal herb used for Qi-regulation and the treatment of anxiety and depression [PMID:38735421].
Background
Citri Reticulatae Pericarpium Viride, also known as Qing Pi or green tangerine peel, is a plant in the Rutaceae family [PMID:38735421]. It is categorized into different commodity specifications, such as Si Hua Qing Pi (SHQP) and Ge Qing Pi (GQP), based on harvesting time [PMID:33977590].
Traditional uses
It is used as a traditional Qi-regulating medicine in Chinese medicine and has extensive clinical practice in treating anxiety and depression [PMID:38735421].
Active compounds
The herb contains biologically valuable flavonoids [PMID:33977590], specifically polymethoxylated flavones (PMFs) including nobiletin (40.5%), tangeretin (45.6%), 5-demethylnobiletin (8.7%), and sinensetin (1.7%) [PMID:17367982]. Other identified compounds include hesperidin, neohesperidin, and naringenin [PMID:12212096, PMID:41475204].
Mechanism of action
Qing Pi essential oil may improve anxiety-like behavior by regulating Glu/NMDAR on the olfactory bulb [PMID:38735421]. Its pharmacological benefits are attributed to antioxidant capacities and neuroprotective effects [PMID:38735421]. Certain polymethoxylated flavonoids in the peel are noted for strong antitumor activity [PMID:35668040].
Clinical evidence
Evidence DAnxiety
Essential oil of Citri Reticulata Pericarpium Viride was evaluated for its ability to improve anxiety-like behavior via Glu/NMDAR regulation in animal models [PMID:38735421]
Evidence BChronic viral hepatitis B with compensated liver cirrhosis
Green tangerine peel was used as a component of the Xiaozhang Recipe (XR) in a clinical trial to assess efficacy alongside lamivudine [PMID:22013800]
Evidence summary
The evidence consists primarily of phytochemical profiling and animal-based pharmacological studies (Level D), with limited clinical trial data (Level B) where the herb is used as part of a multi-ingredient formula.
PubMed sources
- 1.PMID: 33977590 (2021) — Simultaneous quantitative analysis of ten bioactive flavonoids in Citri Reticulatae Pericarpium Viride (Qing Pi) by ultrahigh-performance liquid chromatography and high-resolution mass spectrometry combined with chemometric methods. · Phytochemical analysis : PCA
- 2.PMID: 38735421 (2024) — Neuro-stimulating effect of Citri Reticulata Pericarpium Viride essential oil through regulating Glu/NMDAR on olfactory bulb to improve anxiety-like behavior. · Journal of ethnopharmacology
- 3.PMID: 35668040 (2022) — Rapid profiling of potential antitumor polymethoxylated flavonoids in natural products by integrating cell biospecific extraction with neutral loss/diagnostic ion filtering-based high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. · Phytochemical analysis : PCA
- 4.PMID: 17367982 (2007) — Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. · Journal of pharmaceutical and biomedical analysis