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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Gastrodia elata Blume is a traditional Chinese medicine primarily used to treat nervous system disorders, demonstrating significant neuroprotective and pharmacological activities [PMID:37749449, PMID:40371076].
Background
Gastrodia elata Blume, commonly known as Tian ma, is an achlorophyllous orchid distributed in eastern Asia, including China, Korea, Japan, and India [PMID:27377337, PMID:31291888]. Its tubers, seeds, and stalks are utilized for medicinal, food, and health care purposes [PMID:37689324].
Traditional uses
Traditionally used in Asian countries to treat diseases of the nervous system, including stroke, epilepsy, headache, dizziness, spasms, forgetfulness, infantile convulsion, and tetany [PMID:37749449, PMID:40374368, PMID:27377337]. It has also been used as an analgesic, sedative, anti-asthma, and anti-immune drug [PMID:28698450].
Active compounds
The primary bioactive components include gastrodin, p-hydroxybenzyl alcohol, vanillyl alcohol, polysaccharides, and β-sitosterol [PMID:40371076]. Other identified compounds include phenolic glycosides, steroids, organic acids, and various gastrodin derivatives [PMID:37075984, PMID:31734866].
Mechanism of action
Gastrodin exerts neuroprotection by scavenging reactive oxygen species (ROS), suppressing pro-inflammatory cytokines, and enhancing GABAergic transmission [PMID:40371076]. Neutral polysaccharides (NPGE) alleviate cerebral ischemia-reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2/HO-1 signaling pathway, upregulating GPX4, and lowering ROS and Fe2+ [PMID:37752806]. Gastrodia elata polysaccharides (GEP) may alleviate depression by modulating gut microbiota and activating the Keap1-Nrf2/BDNF-TrkB pathway [PMID:40447013].
Clinical evidence
Evidence CNeurological Disorders (General)
Demonstrates therapeutic efficacy supported by robust clinical evidence for treating neurological disorders [PMID:40371076].
Evidence DCerebral Ischemia-Reperfusion Injury
Neutral polysaccharides (NPGE) decreased neurological deficits, reduced infarct volume, and alleviated cerebral edema in mouse models [PMID:37752806].
Evidence DDepression
GEP pretreatment effectively mitigated depressive behavior in mice induced by chronic unpredictable mild stress and lipopolysaccharide [PMID:40447013].
Evidence DParkinson's Disease
GEP improved motor function, reduced dopaminergic neuron loss, and suppressed microglial activation and NLRP3 inflammasome components in MPTP-induced PD mice [PMID:40796532].
Evidence DLiver Injury
Gastrodia elata rhizome significantly reduced liver injury in dogs induced by thioacetamide, as evidenced by lowered ALT, ALP, and NO levels [PMID:37534070].
Evidence D
Evidence summary
The evidence is primarily based on narrative reviews (Level C) and preclinical animal or in vitro models (Level D), with mentions of robust clinical evidence in reviews, though specific clinical trial data were not provided in the abstracts.
PubMed sources
1.PMID: 37749449 (2023) — Review on pharmacological effects of gastrodin. · Archives of pharmacal research
2.PMID: 37752806 (2024) — Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia-reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2/HO-1 signaling pathway. · CNS neuroscience & therapeutics
3.PMID: 40447013 (2025) — Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation. · International journal of biological macromolecules
4.PMID: 31734866 (2019) — Gastrodin Derivatives from Gastrodia elata. · Natural products and bioprospecting
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G. elata extract (GE05) improved survival rates and protected against lung injury by downregulating the IL-23/IL-17 A axis [PMID:40398516].
Evidence DSleep Disturbances
Fermented Gastrodia elata (FGE) attenuated PTZ-induced insomnia behavior and circadian rhythm disturbances in zebrafish via the microbiota-gut-brain axis [PMID:40597484].
— Neuropharmacological effects of Gastrodia elata Blume and its active ingredients.
· Frontiers in neurology
6.PMID: 27765372 (2016) — Gastrodia elata and epilepsy: Rationale and therapeutic potential. · Phytomedicine : international journal of phytotherapy and phytopharmacology
7.PMID: 40374368 (2025) — The Pharmacological Effects of Gastrodin and the Progress in the Treatment of Neurological Disorders. · The American journal of Chinese medicine
8.PMID: 40408941 (2025) — Neuroprotective effects of Gastrodia elata and its compounds in a Caenorhabditis elegans Alzheimer's disease model. · Phytomedicine : international journal of phytotherapy and phytopharmacology
9.PMID: 27377337 (2016) — The rhizome of Gastrodia elata Blume - An ethnopharmacological review. · Journal of ethnopharmacology
10.PMID: 40796532 (2025) — Gastrodia elata Polysaccharide Ameliorates Parkinson's Disease by Enhancing Dopamine Levels, Inhibiting NLRP3 Inflammasome Activation, and Promoting Mitochondrial Autophagy. · The American journal of Chinese medicine
11.PMID: 28698450 (2017) — Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents. · Molecules (Basel, Switzerland)
12.PMID: 37075984 (2023) — Gastrodia elata Blume: A review of its mechanisms and functions on cardiovascular systems. · Fitoterapia
14.PMID: 1842007 (1991) — Bioactive glycosides from Chinese medicines. · Memorias do Instituto Oswaldo Cruz
15.PMID: 31269719 (2019) — Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities. · Molecules (Basel, Switzerland)
16.PMID: 37114145 (2023) — Gastrodia elata BI.:A Comprehensive Review of Its Traditional Use, Botany, Phytochemistry, Pharmacology, and Pharmacokinetics. · Evidence-based complementary and alternative medicine : eCAM
17.PMID: 33424999 (2020) — Gastrodia elata Blume (Tianma): Hope for Brain Aging and Dementia. · Evidence-based complementary and alternative medicine : eCAM
18.PMID: 37534070 (2023) — Gastrodia elata rhizoma ameliorates thioacetamide-induced liver injury in dogs. · Journal of advanced veterinary and animal research
19.PMID: 39015542 (2024) — Research progress of Gastrodia elata Blume polysaccharides: a review of chemical structures and biological activities. · Frontiers in chemistry
20.PMID: 39009105 (2024) — Experimental study on the detection of Gastrodia elata by enzymatic recombinase amplification and immunochromatography. · Analytical biochemistry
21.PMID: 40597484 (2025) — Fermented Gastrodia elata Bl. Intervenes gut microbiota and amino acid metabolism in zebrafish to promote 5-HT homeostasis against sleep disturbances. · Food research international (Ottawa, Ont.)
23.PMID: 40868260 (2025) — An Overview of the Role of Medicinal Plants in Parkinson's Disease: A Semi-Systematic Review. · Biomedicines
24.PMID: 17381154 (2007) — Neuroprotective principles from Gastrodia elata. · Journal of natural products
25.PMID: 31291888 (2019) — Dynamics of fungal communities during Gastrodia elata growth. · BMC microbiology
26.PMID: 38056151 (2024) — Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties. · Phytomedicine : international journal of phytotherapy and phytopharmacology
27.PMID: 26416021 (2015) — Pharmacokinetic study of Gastrodia elata in rats. · Analytical and bioanalytical chemistry
28.PMID: 37689324 (2024) — Traditional uses, phytochemistry, pharmacology, applications, and quality control of Gastrodia elata Blume: A comprehensive review. · Journal of ethnopharmacology
29.PMID: 26013819 (2015) — 4-Hydroxybenzyl-substituted glutathione derivatives from Gastrodia elata. · Journal of Asian natural products research