PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Attenuated elevation of blood pressure and inhibited cardiac fibrosis in angiotensin II-induced mouse models [PMID:35062072].
Exerts neuroprotective activity and protects dopaminergic neurons via activating mitophagy [PMID:39471877, PMID:29940559].
Reported to have neuroprotective effects and potential for alleviating dementia [PMID:31272356, PMID:21791295, PMID:39170707].
Hirsutine (an alkaloid from U. rhynchophylla) improved peripheral hyperglycemia, glucose tolerance, and attenuated hepatic steatosis and cardiac hypertrophy in high-fat diet-induced diabetic mice [PMID:34597809].
Alkaloids appear to have positive effects on methamphetamine and ketamine addiction [PMID:28807162].
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 36797057 (2023) — Identification of PXR Activators from Uncaria Rhynchophylla (Gou Teng) and Uncaria Tomentosa (Cat's Claw). · Drug metabolism and disposition: the biological fate of chemicals
- 2.PMID: 35178951 (2022) — [Steroids from Uncaria rhynchophylla]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- 3.PMID: 34597809 (2022) — Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models. · Pharmacological research
- 4.PMID: 28657449 (2017) — Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng). · European journal of mass spectrometry (Chichester, England)
- 5.PMID: 39170707