PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Used as a traditional medicinal plant for management; research focuses on litholytic parameters and inhibition of calcium oxalate renal stones [PMID: 40318530, PMID: 40648041]
Aqueous ethanol extract of Lygodii Spora (spores) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity in animal models (hamsters and mice) [PMID: 12033503]
Evidence summary
PubMed sources
- 1.PMID: 40648041 (2025) — Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review. · Plants (Basel, Switzerland)
- 2.PMID: 40318530 (2025) — Structural characterization of polysaccharides from Lygodium japonicum (Thunb.) Sw. and its inhibition ability in calcium oxalate renal stone. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 3.PMID: 19132289 (2009) — A new ecdysteroside from Lygodium japonicum (Thunb.) Sw. · Journal of natural medicines
- 4.PMID: 23154839 (2012) — Unusual 9,19 : 24,32-dicyclotetracyclic triterpenoids from Lygodium japonicum. · Planta medica
- 5.PMID: 40612605 (2025)