PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Fruit extract significantly improved hyperlipidemia in high-fat diet-fed mice by increasing hepatic PPARα expression [PMID:21823058]
Leaf flavonoids attenuated the development of atherosclerotic lesion areas in apoE knock-out mice [PMID:28119096, 38442806]
Crataegus pinnatifida polysaccharide alleviated DSS-induced colitis in mice by regulating intestinal microbiota and short-chain fatty acids [PMID:40315641]
Shan Zha was sufficient to produce anxiolytic and antidepressant-like effects in stressed mice [PMID:35589704]
Hyperoside mitigated NAFLD in rats [PMID:40349961]; Leucocyanidin reduced liver weight, serum TG/TC, and hepatic inflammation in mouse models [PMID:41365192]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 40315641 (2025) — Crataegus pinnatifida polysaccharide alleviates DSS-induced colitis in mice by regulating the intestinal microbiota and enhancing arginine biosynthesis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 38327605 (2023) — Effect of Shan Zha (Hawthorn or Crataegus) on gastrointestinal cancer: A network pharmacology and molecular docking study. · Cancer pathogenesis and therapy
- 3.PMID: 40349961 (2026) — Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease. · Journal of advanced research
- 4.PMID: 35589704 (2022) — Anxiolytic and antidepressants' effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms. · Translational psychiatry
- 5.PMID: 36228891