PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Active compounds
Mechanism of action
Clinical evidence
Pennogenyl saponins (PS 1 and PS 2) strongly inhibited tumor cell growth (IC50 1.11 and 0.87 µg/ml) and induced dose-dependent apoptosis [PMID:26295969]
Ethanol extracts and isolated pennogenyl saponins demonstrated cytotoxic effects against these tumor cell lines [PMID:24991111]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 24991111 (2014) — Isolation and identification of cytotoxic compounds from the rhizomes of Paris quadrifolia L. · Pharmacognosy magazine
- 2.PMID: 23413750 (2012) — Chemical composition and biological activity of Paris quadrifolia L. · Zeitschrift fur Naturforschung. C, Journal of biosciences
- 3.PMID: 16313608 (2005) — Local forest environment largely affects below-ground growth, clonal diversity and fine-scale spatial genetic structure in the temperate deciduous forest herb Paris quadrifolia. · Molecular ecology
- 4.PMID: 26295969 (2015) — Pennogenyl Saponins from Paris quadrifolia L. Induce Extrinsic and Intrinsic Pathway of Apoptosis in Human Cervical Cancer HeLa Cells. · PloS one
- 5.PMID: 16341715 (2006)