PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
A randomized, double-blind, placebo-controlled study found that fermented C. intermedia extract (400-800 mg/day) significantly improved global skin wrinkle grade and skin hydration over 12 weeks [PMID:29388846].
In hairless mice, honeybush extract and fermented honeybush reduced the length and depth of UV-induced skin wrinkles and suppressed collagen tissue breakdown [PMID:25355549].
A polyphenol-enriched fraction of C. intermedia reduced lipid content in adipocytes and inhibited body weight gain in obese diabetic db/db mice [PMID:36835279].
Topical application of honeybush fractions significantly suppressed skin tumorigenesis in a two-stage mouse skin carcinogenesis assay [PMID:15914270].
Extracts of C. genistoides and C. subternata inhibited antigen-antibody-induced degranulation and suppressed anaphylactic reactions in a murine model [PMID:38966058].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 16927447 (2007) — A review of the bioactivity of South African herbal teas: rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia). · Phytotherapy research : PTR
- 2.PMID: 15315375 (2004) — Phenolic metabolites from honeybush tea (Cyclopia subternata). · Journal of agricultural and food chemistry
- 3.PMID: 32831989 (2020) — Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury. · Oxidative medicine and cellular longevity
- 4.PMID: 12797758 (2003) — Polyphenols from Honeybush tea (Cyclopia intermedia). · Journal of agricultural and food chemistry
- 5.PMID: 27367721 (2016) — Mangiferin and Cancer: Mechanisms of Action.