PubMed-compiled information sheet
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Compiled from 5 PubMed articles · model: gemma4:31b
Summary
Huanarpo Macho (Jatropha macrantha) is a plant used in Peruvian traditional medicine as an aphrodisiac and for erectile dysfunction [PMID:35011347].
Background
Jatropha macrantha Müll Arg., also known as "huanarpo macho," is a plant species utilized in Peruvian folk medicine [PMID:35011347, PMID:14600359].
Traditional uses
It is used in Peruvian traditional medicine as an aphrodisiac and for the treatment of erectile dysfunction (ED) [PMID:35011347].
Active compounds
Identified compounds include triterpenoids such as pomolic acid and euscaphic acid [PMID:32691666], as well as catechin, catechin-7-O-beta-glucopyranoside, proanthocyanidin B-3, and other catechin polymers [PMID:16300918].
Mechanism of action
Triterpenoids isolated from J. macrantha inhibit the NF-κB and HIF-1α pathways in tumour cell lines, including SK-MEL-28, A549, and U-373 MG [PMID:32691666].
Clinical evidence
Evidence DErectile Dysfunction
The ethyl acetate fraction from leaves and stems was studied for its ameliorative effect on ketamine-induced erectile dysfunction in rats [PMID:35011347]
Evidence DHormonal Levels
In mice, testosterone levels increased significantly when J. macrantha was administered in combination with Lepidium meyenii Walp, though no marked changes were seen in estradiol-17beta or embryo implantation rates [PMID:14600359]
Evidence summary
The current evidence is limited to preclinical studies (in vitro cell lines and animal models), providing low-level evidence (Level D) for its traditional uses and biological activities.
PubMed sources
- 1.PMID: 32691666 (2021) — Triterpenoids isolated from Jatropha macrantha (Müll. Arg.) inhibit the NF-κB and HIF-1α pathways in tumour cells. · Natural product research
- 2.PMID: 35011347 (2021) — Phytochemical Screening by LC-ESI-MS/MS and Effect of the Ethyl Acetate Fraction from Leaves and Stems of Jatropha macrantha Müll Arg. on Ketamine-Induced Erectile Dysfunction in Rats. · Molecules (Basel, Switzerland)
- 3.PMID: 14600359 (2003) — Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17 beta, progesterone, testosterone and the rate of embryo implantation in mice. · The Journal of veterinary medical science
- 4.PMID: 16300918 (2006) — Catechin derivatives in Jatropha macrantha stems: characterisation and LC/ESI/MS/MS quali-quantitative analysis. · Journal of pharmaceutical and biomedical analysis
- 5.PMID: 17462632